Lung cancer cells

These arotinoids, which were first introduced for the treatment of skin diseases, may also have potential as anticancer diugs. For example, the synthetic retinoid 6-[3-(l-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) has been shown to induce apoptosis in a variety of cancer cells including lung cancer cells in vitro, and studies concerning the use of this agent in vivo would be desirable. 

In addition, several other organs, like the heart, ovaty, amnion, chorion, decidua, testis, epididymis and prostate, have been reported to synthesize OT, suggesting a paracrine role for this hormone in these tissues. Ectopic AVP production by lung cancer cells or other neoplasms has been described in humans, leading to the syndrome of inappropriate antidiuretic hormone secretion. 

OKABE s, SUGANUMA M, HAYASHi M, SUEOKA E, KOMORI A and FUJIKI H (1997) Mechanisms of growth inhibition of hmnan lung cancer cell line, PC-9, by tea polyphenols , Jpn J Cancer Res, 88 (7), 639-43. 

SUGANUMA M, OKABE s, KAi Y, suEOKA N, suEOKA E and FUJiKi H (1999) Synergistic effects of (-)-epigallocatechin gallate with (-)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in human lung cancer cell line PC-9 , Cancer Res, 59, 44-7. 

Liu, L.Z. et al., Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells implication of chemoprevention of lung cancer, Mol. Pharmacol., 68, 635, 2005. 

Kijima T, Maulik G, Ma PC, et al. Regulation of cellular proliferation, cytoskeletal function and signal transduction through CXCR4 and c-kit in small cell lung cancer cells. Cancer Res 2002 62 6304-6311. 

Zhu YM, Webster SJ, Flower D, Woll PJ. Interleukin-8/CXCL8 is a growth factor for human lung cancer cells. Br J Cancer 2004 91 1970-1976. 

Lian, E, K. Q. Hu, R. M. Russell, and X. D. Wang. 2006. Beta-cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non-small-cell lung cancer cells and up-regulates retinoic acid receptor beta expression. Int J Cancer 119(9) 2084—2089. 

Lian, F., D. E. Smith, H. Ernst, R. M. Russell, and X. D. Wang. 2007. Apo-lO -lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. Carcinogenesis 28(7) 1567-1574. 

Brognard, J., Clark, A.S., Ni, Y., and Dennis. P.A. 2001. Akt/protein kinase b is constitutively active in nonsmall cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. 

Fukunaga, Y., Bandoh, S., Fujita, J., Yang, Y., Ueda, Y., Hojo, S., Dohmoto, K., Tojo, Y., Takahara, J., Ishida, T. (2002). Expression of cytokeratin 8 in lung cancer cell lines and measurement of serum cytokeratin 8 in lung cancer patients. Lung Cancer 38(1), 31-38. 

Cole SPC, Bhardwaj G, Gerlach J, Mackie J, Grant C, Almquist K et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 1992 258 1650-1654. 

Mirski, S.E., Gerlach, J.H. and Cole, S.P. (1987) Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin. Cancer Research, 47, 2594-2598. 

Berger W, Elbling L, Micksche M (2000) Expression of the major vault protein LRP in human non-small-cell lung cancer cells Activation by short-term exposure to antineoplastic drugs. Int J Cancer 88(2) 293-300. 

Bey EA, Bentle MS, Reinicke KE, Dong Y, Yang CR, Girard L, Minna JD, Bommann WG Gao J, Boothman DA. (2007) An NQOl- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone. Proc Natl Acad Sci USA 104 11832-11837. 

Lin, R.K., Hsu, C.H. and Wang, YC. (2007) Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells. Anti-Cancer Drugs, 18, 1157-1164. 

Roche has reported a 2,4-diaminopyrimidine 42 (Ro-4584820) to be a Phase I clinical candidate [48,103]. Compound 42 is a pan-CDK inhibitor (CDKl K = 0.001 ptM CDK2 K[ = 0.003 p.M CDK4 K[ = 0.001 p.M), consequently it induces both G1 and G2 cell cycle arrest in tumor cell lines. It is a potent inhibitor of tumor cell proliferation in both the HCT-116 colon cancer (IC50 = 0.080 tiM) and the H460A (IC50 = 0.055 p.M) lung cancer cell lines. 

Ikegami Y, Yano S, Nakao K (1996a) Antitumour effect of CGP 41251, a new seledive protein kinase C inhibitor on human non-small cell lung cancer cells. Jpn J Pharmac 70 65-72... 

Kim CY, Giaccia AJ, Strulovici B, Brown JM (1992) Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation. Br Cancer 66 844-849... 

Shimizu E, Zhao MR, Nakanishi H, Yamamoto A, Yoshida S, Takada M, Ogura T, Sone S (1996) Differing effects of staurosporine and UCN-01 on RB protein phosphorylation and expression of lung cancer cell lines. Oncology 53 494-504... 

---