Liver carcinoma

Arsenic and certain compounds Skin, lung, liver - carcinoma... 

Reuber, M.D. and J.M. Ward. 1979. Histopathology of liver carcinomas in (C57BL/6N X C3H/HeN) F, mice ingesting chlordane. Jour Natl. Cancer Inst. 63 89-92. 

Male B6C3F1 mice exposed to 0.1 g/1 chloroacetaldehyde via the drinking water for 104 weeks (mean ingested dose 17/mg/kg/day) had a significant increase in the prevalence of liver carcinomas (31% vs. 10% in controls). No... 

Four of four beagle dogs administered DCB by capsule for 7 years had bladder papillary transitional cell carcinoma and three had liver carcinoma untreated controls had no liver or bladder neoplasms. ... 

Two of 10 dogs survived ingestion of 20mg/kg/day for 38 months of continuous treatment followed by 48 months of intermittent treatment both developed bladder papillomas. Oral administration of 1, 3, 10, 20, or 30mg/day produced liver tumors in rats the induction time was inversely proportional to the daily dose, ranging between 34 days for the 30mg/day dose and 700 days for the 1 mg/day dose. In rats fed 5 mg DAB/day for 40-200 days and then kept for their life span on a normal diet, there was a 20-81% incidence of liver carcinoma."... 

Chronic oral exposure to heptachlor increased the incidence of liver carcinomas in three species of mice and one species of rats. A study of two cohorts of workers exposed to chlordane and heptachlor at two different production facilities failed to demonstrate any overall excess of cancer. There was one death from liver cancer with 0.59 expected. There was a slight excess of lung cancer (12 observed. 

Mice fed heptachlor epoxide in the diet at lOmg/kg for 24 months showed a significant excess of liver carcinomas. In another study, an excess of liver carcinomas was observed in female rats given 5 and lOmg/kg in the diet. ... 

Prolonged administration may increase risk of gallbladder, thromboembolic disease, breast, cervical, vaginal, endometrial, and liver carcinoma. 

Male B6C3Fi mice, four weeks of age, received a single intraperitoneal injection of 80 mg/kg bw NDEA in tricaprylin and, two weeks later, were fed diets containing 0, 3000, 6000 or 12 000 ppm di(2-ethylhexyl) phthalate (purity, 99%) for up to 18 months. Groups of 10-20 mice were killed at two, four, six or 18 months. The numbers of mice with hepatocellular foci, adenomas and carcinomas were determined. All doses of di(2-ethylhexyl) phthalate increased the numbers of all lesions at the time periods studied compared with mice receiving NDEA alone. At 18 months, carcinomas were found in 3/10 mice treated with NDEA alone and in 10/10 and 18/20 mice treated with NDEA + di(2-ethylhexyl) phthalate at the low and mid doses, respectively. All mice given 12 000 ppm di(2-ethylhexyl) phthalate with NDEA initiation died by nine months and 11/20 had liver carcinomas. In mice treated with di(2-ethylhexyl) phthalate alone, 2/30 had liver carcinomas (Ward et al, 1986). 

The treatment of rats, both male and female, for two years with tamoxifen revealed a dose-related increase in malignant liver tumors (Table 7.2). Thus, the table indicates that liver carcinomas caused by tamoxifen show a dose-related increase in both sexes, with a similar incidence, and metastases showed a slight but similar incidence. Research by various groups on the mechanisms underlying the carcinogenicity of tamoxifen has been extremely important in assessing the risk from this important drug and has allowed it to continue to be used. 

Some ring-substituted (hydroxy or methoxy) camptothecin derivatives were either isolated in nature or obtained synthetically [253,264-267]. The 9-methoxy- and 10-methoxycamptothecin are less active, but 10-hydroxy-camptothecin is more active than the parent alkaloid against leukaemia P388 [253, 264], Both camptothecin and its 10-hydroxy derivative are being used in mainland China for the treatment of liver carcinoma and tumours of the head... 

Trichloroethylene has caused liver carcinoma in experimental animals and is a suspect human carcinogen, although a recent review of the literature has concluded that it would be wholly inappropriate to classify trichloroethylene as a human carcinogen. 8 Numerous body organs are... 

Serum proteins from cell culture medium PDMS Human liver carcinoma cells Photocatalitc hydrophilization of PDMS (mask lithography) 2009 [163]... 

Fibronectin, collagen Photoreactive PVA modified with phenylazido groups Monkey kidney fibroblasts, murine macrophage-like cells, human liver carcinoma cells, mouse embryonic fibroblasts tCP of proteins onto hydrogel background and subsequent photoactivated immobilization 2005 [90]... 

Cispifltln-resiaiani ovarian cancer ceils melphalan-reslstant prostale cancer cells a lung cancer cell line SBC3 a liver carcinoma cell line HepG2 cells... 

Toxicity and health effects Laboratory rats exposed to 2-nitropropane in high concentrations (207 ppm) developed adverse liver changes like hepatocellular hypertrophy, hyperplasia, necrosis, and liver carcinoma. It has been reported that prolonged exposure to concentrations of 20-45 ppm of 2-nitropropane caused nausea, vomiting, diarrhea, anorexia, and severe headaches among workers. Industrial workers handling 2-nitropropane for the application of epoxy resins to the walls of a nuclear power plant developed toxic hepatitis. - ... 

Bladder - carcinoma Skin, lung, liver — carcinoma Respiratory tract — carcinoma Pleura and peritoneum -mesothelioma... 

UCR = (slope for liver carcinoma) -i- (slope for renal carcinoma)... 

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