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Drug selectivity

Hopkins, A. L., Groom, C. R., and Alex, A. (2004). Ligand efficiency A useful metric for lead selection. Drug Disc. Today 9 430-431. [Pg.172]

Roth BL, Sheffler DJ, Kroeze WK (2004) Magic shotguns versus magic bullets selectively non-selective drugs for mood disorders and schizophrenia. Nat Rev Drug Discov 3 353-359... [Pg.355]

DISPLAY 49-1 Select Drugs That Decrease the Hypoglycemic Effect of Insulin... [Pg.491]

Over the last ten years or so, the emphasis on selectivity of action has waned. This is because the relative importance of blocking noradrenaline and 5-HT reuptake remains uncertain and it is possible that it could be beneficial to block both. Some drugs that act in this way have already been developed. It is hoped that this approach might increase the response rate of patients who are resistant to more selective drug treatments and even reduce the therapeutic lag that dogs their predecessors. As yet, there is not enough information on these compounds to know whether or not this has turned out to be the case. [Pg.441]

Halliwell, B. (1991). Drug antioxidant eflfects. A basis for drug selection Drugs 42, 469-605. [Pg.110]

Dose of Fluoxetine N Percentage Selecting Drug Lever... [Pg.13]

Baxter, B.L. The effect of selected drugs on the emotional behavior elicited via hypothalamic stimulation. Int J Neuropharmacol 7 47-54,... [Pg.91]

The goal of this chapter is to review recent morphologic studies in which current anatomic me ods have been used to characterize the neurotoxic effects of psychoactive amphetamine derivatives. Several strategies combining anatomic with biochemical data have been employed to analyze the effects of selected drugs in this class. These studies show that psychoactive drugs that have selective neurotoxic effects can be useful experimental tools to study the neural mechanisms of elusive brain functions such as affective state control and perceptual integration. [Pg.270]

Nakatani, K. Matsuno, T. Adachi, K. Hagihara, S. Saito, I. Selective intercalation of charge neutral intercalators into GG and CG steps implication of HOMO-LUMO interaction for sequence-selective drug intercalation into DNA. J. Am. Chem. Soc. 2001, 123, 5695-5702. [Pg.267]

Recommend appropriate monitoring parameters and patient education for selected drug regimens for treating symptoms of IBD. [Pg.281]

TABLE 18-3. Selected Drugs and Substances That May Cause Acute Diarrhea... [Pg.312]

Describe drug desensitization procedures for selected drugs. ... [Pg.819]

TABLE 60-11. Selected Drug-Induced Ocular Changes... [Pg.947]

Creams and lotions may be used in animals, although they can be licked off by the patient and must be used with caution. Table 1 presents the doses and recommended dosage frequencies for selected drugs in small animals. [Pg.728]

Breinholt, V., S. T. Lauridsen, B. Daneshvar, and J. Jakobsen. 2000. Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat. Cancer Lett 154(2) 201-210. [Pg.430]

Table 9.4 Metabolite production of selected drugs using human cytochrome biocatalysts available from Codexis, Inc"... [Pg.221]

Fig. 4.4. A current trend in drug transport studies is to use simplified cell models that facilitate the characterisation of selected drug transport mechanisms. However, recent research suggests that such simplified systems are not useful in cases where two or more drug transporters act in synergy. Development of cell models for such complex transport mechanisms will require the technically... Fig. 4.4. A current trend in drug transport studies is to use simplified cell models that facilitate the characterisation of selected drug transport mechanisms. However, recent research suggests that such simplified systems are not useful in cases where two or more drug transporters act in synergy. Development of cell models for such complex transport mechanisms will require the technically...
Sietsema, W. K., The absolute oral bioavailability of selected drugs, Int. J. Clin. Pharmacol. Ther. Toxicol. 1989,... [Pg.459]

O Differential effects of compounds - in vivo or in vitro - on gene expression, among the entirety of expressed genes O Assessed by expression profiling O A tool for compound selection/drug discovery... [Pg.128]


See other pages where Drug selectivity is mentioned: [Pg.201]    [Pg.232]    [Pg.45]    [Pg.49]    [Pg.997]    [Pg.525]    [Pg.303]    [Pg.315]    [Pg.393]    [Pg.287]    [Pg.329]    [Pg.75]    [Pg.61]    [Pg.405]    [Pg.456]    [Pg.280]    [Pg.460]    [Pg.185]    [Pg.467]    [Pg.141]    [Pg.220]    [Pg.141]    [Pg.809]    [Pg.1083]    [Pg.22]    [Pg.636]    [Pg.800]    [Pg.206]    [Pg.168]    [Pg.88]    [Pg.478]   
See also in sourсe #XX -- [ Pg.6 , Pg.45 , Pg.45 ]




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Anticancer drugs selective toxicity

Antihypertensive drugs selection

Antiinflammatory drugs, nonsteroidal selection

Antimicrobial agents/drugs selection

Antiparasitic drugs selective toxicity

Antipsychotic drugs selective serotonin reuptake inhibitors with

Antitumor drugs selective toxicity

Application of the Methodology to Selected Drugs

Beta-blocking drugs selectivity

Bioavailability testing drug product selection

Biopharmaceutics candidate drug selection

Bioreductive drug selectivity

COX-2-selective nonsteroidal anti-inflammatory drugs

Candidate drug salt selection

Candidate drug selection biopharmaceutical support

Candidate drug selection lead identification

Candidate drug selection preformulation

Candidate drug selection, preferred

Chemical formulas selected drugs

Cleaning Dirty Drugs with Selectivity Filters Basic Insights

Compound selection drug properties

Developing countries drug selection

Drug action selectivity

Drug candidate selection

Drug delivery intestine-selective

Drug delivery kidney-selective

Drug delivery selective

Drug delivery selectivity

Drug delivery site-selective

Drug delivery systems vehicle selection

Drug delivery tumor-selective

Drug design lead’ structure selection

Drug discovery stages candidate selection

Drug products, formulation development excipient selection

Drug products, formulation development state selection

Drug selection

Drug selection

Drug selection genomics

Drug selective electrode

Drug target selection

Drug validation methods selection

Drugs dose selection

Drugs, chiral selected single compounds

Elimination half life selected drugs

Formulary systems drug selection

Hypoxia-selective cytotoxins drugs

In Vitro Profiling Drug Activity, Selectivity and Liability

Kinetics controlling bioreductive drug selectivity towards hypoxic cells

Look up the names of both individual drugs and their drug groups to access full information Selective serotonin re-uptake inhibitors (

Lung Model Selection for Drug Absorption Studies

Medication errors drug selection

Membranes drug design selectivity

National drug policies selection

Nonsteroidal anti-inflammatory drugs selective

Nonsteroidal anti-inflammatory drugs selective cyclooxygenase-2 inhibitors

Predicting Selectivity and Druggability in Drug Discovery

Pregnancy drug selection

Pulmonary drug delivery selectivity

Quantitative structure-activity relationships selective drug design

SELECTED DRUGS AND THEIR MECHANISMS OF ACTION

Selected Drugs from Early Recorded History

Selected Examples of Drug Action at some Common Target Areas

Selected drug transporters

Selected drug transporters INDEX

Selecting a Receptor Appropriate for Drug Design

Selection drug factors

Selection of Drugs

Selection, natural product drug

Selection, natural product drug development

Selective Drug Delivery for the Treatment of Other Hepatic Disorders

Selective delivery of drugs

Selective drugs, activity toward

Selective drugs, activity toward receptors

Selective estrogen receptor modulators drugs

Selective serotonin reuptake inhibitors drug administration

Selective serotonin reuptake inhibitors drug interactions

Selective serotonin reuptake inhibitors drug overdose

Selective serotonin reuptake inhibitors drug withdrawal

Selective serotonin reuptake inhibitors drugs

Selective toxicity antifungal drugs

Selective toxicity antiparasite drugs

Selective toxicity antiviral drugs

Selectivity drug design

Serotonin reuptake inhibitors, selective interaction with other drugs

Solubility candidate drug salt selection

Stability candidate drug salt selection

Target-selective drug design

Therapeutic range selected drugs

Tumour-selective drug delivery

Using Drug Resistance as a Selection Technique

Wrapping as a Selectivity Filter An Exercise in Drug Design

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