Hypoglycemic effect

Sulfonylureas. The hypoglycemic effect of sulfonylureas was first noted in the early 1940s when several patients died in hypoglycemic coma after testing glyprothia2ole, a synthetic sulfonamide used to treat typhoid. Chemical modifications which enhanced activity and lowered toxicity led to the development of the first-generation sulfonylureas. Carbutamide [339-43-5] the first commercial sulfonylurea, came onto the European... 

When certain drug s are administered with insulin, a resultant decrease or increase in hypoglycemic effect can occur. Display 49-1 identifies selected dragp that decrease the hypoglycemic effect of insulin. 

DISPLAY 49-1 Select Drugs That Decrease the Hypoglycemic Effect of Insulin... 

When oral antidiabetic drug are combined with other antidiabetic drug (eg, sulfonylureas) or insulin, the hypoglycemic effect may be enhanced. Elderly, debilitated, or malnourished patients are more likely to experience hypoglycemia... 

Subcutaneous injection of insulin encapsulated in liposomes in rats resulted in prolonged hypoglycemic effects compared to a solution of free insulin this study also indicated that a substantial fraction of hand-shaken multilamellar vesicles could enter the circulation in intact form after subcutaneous injection (Stevenson et al., 1982). The neutral liposomes used in this study were cleared more slowly from the injection site than the negatively charged liposomes. 

Prolonged hypoglycemic effect in diabetic dogs due to subcutaneous administration of insulin liposomes, Diabetes, 31. 506-511. 

The addition of PEG to the gels was critical because the PEG chains participate in the macromolecular complexes, function as a peptide stabilizer and enhance the mucoadhesive characteristics of the gels. In this work, strong dose-dependent hypoglycemic effects were observed in healthy and diabetic rats following oral administration of these gels. 

Camacho-Ibanez R, Meckes-Lozoya M and Mellado-Campos V. 1983. The hypoglycemic effect of Opuntia streptacantha studied in different animal experimental models. J Ethnopharmacol 7 175-181. 

Frati AC, Gordillo BE, Altamirano P, Ariza CR, Cortes-Franco R and Chavez-Negrete A. 1990a. Acute hypoglycemic effect of Opuntia streptacantha Lemaire in NIDDM. Diabetes Care 13 155 156. 

Frati AC, Jimenez E and Ariza CR. 1990b. Hypoglycemic effect of Opuntia ficus-indica in non-insulin dependent diabetes mellitus patients. Phytother Res 4 195—197. 

Increased or decreased antidepressant response increased toxicity Decreased antihypertensive efficacy Decreased antihypertensive efficacy Increased hypoglycemic effects Possible additive lowering of seizure threshold Decreased antihypertensive efficacy tachycardia CNS stimulation Increased therapeutic and possibly toxic effects of both drugs hypertensive crisis delirium seizures hyperpyrexia serotonin syndrome Increased hypoglycemic effects... 

A sesquiterpene glycoside, nerolidol-3-O-a-L-rhamnopyranosyl (l )-a-L-rhamnopyranosyl (1 2)-[a-L-rhamnopyranosyl(1 6)]-P-D-glucopyranoside (66) isolated from Eriobotrya japonica (Thunb.) Lindl. (family Rosaceae), showed a significant (p < 0.05) hypoglycemic effect in alloxan-induced diabetic rats when administered orally to alloxan-diabetic mice at doses of 25 and 75 mg/kg however, the dosage... 

Chen T-H, Chen S-C, Chan P, Chn Y-L, Yang H-Y, Cheng J-T. (2005) Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. Planta Me die a 71 108-113. 

Chen J, Fi WL, Wu JL, Ren BR, Zhang HQ. (2008) Hypoglycemic effects of a sesquiterpene glycoside isolated from leaves of loquat (Eriobotrya japonica (Thunb.) Lindl.). Phytomedicine 15 98-102. 

Hnatyszyn O, Mino J, Ferraro G Acevedo C. (2002) The hypoglycemic effect of Phyllanthus sellowianus fractions in streptozotocin-induced diabetic mice. Phytomedicine 9 556-559. 

Andrade-Cetto A, Wiedenfeld H. (2001) Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J Ethnopharm 78 145-149. 

Banskota AH, Nguyen NT, Tezuka Y, Nobukawa T, Kadota S. (2006) Hypoglycemic effects of the wood of Taxus yunnanensis on streptozotocin-induced diabetic rats and its active components. Phytomedicine 13 109-114. 

Bajpai MB, Asthana RK, Sharma NK, Chatterjee SK, Mukheijee SK. (1991) Hypoglycemic effect of swerchirin from the hexane fraction of Swertia chirayita. Planta Med 57 102-104. 

Kamiya K, Hamabe W, Harada S, Murakami R, Tokuyama S, Satake T. (2008) Chemical constituents of Morinda citrifolia roots exhibit hypoglycemic effects in xtreptozotocin-induced diabetic mice. Biol Pharm Bull 31 935-938. 

Noorshahida A, Wong TW, Choo CY. (2009) Hypoglycemic effect of qnassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds. J Ethnopharmacol 124 586-591. 

Oe H, Ozaki S. (2008) Hypoglycemic effect of 13-membered ring thiocy-clitol, a novel a-glucosidase inhibitor from Kothala-himbutu Salacia reticulata). Biosci Biotechnol Biochem 72 1962-1964. 

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