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Candidate drug selection biopharmaceutical support

Ungell, A.-L., Abrahamsson, B., Biopharmaceutical support in candidate drug selection, in Pharmaceutical Preformulation and Formulation. A Practical Guide from Candidate Drug Selection to Commercial Dosage Formulation. Gibson, M. (ed.), Interpharm Press, 2001. [Pg.120]

The present chapter focuses on aspects of drug solubility/dissolution of specific relevance for biopharmaceutical support in candidate drug selection and preformulation. These aspects include solubility in candidate drug screening, physiological aspects of test media, solubility of amphiphilic drugs and substance characterisation prior to solubility/dissolution tests. [Pg.101]

This chapter is strongly focussed on oral drug delivery. The relevant principles and methods involved in biopharmaceutical characterisation of a drug molecule, mainly applied in the preformulation phase, are described in Chapter 4, Biopharmaceutical Support in Candidate Drug Selection . [Pg.240]


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