Therapeutic range selected drugs

The selection of a vehicle can dramatically affect delivery and consequently efficacy of topical preparations. In terms of transdermal delivery, where delivering therapeutic agents for systemic effects is desired, solvents and co-solvent systems are widely used to improve both the amount and range of drugs that can be administered at therapeutic levels through the skin. Vehicles used in transdermal systems, such as patches, have recently been reviewed (Williams, 2003). In contrast, the focus of this chapter is on the use of solvents in topical dosage forms, i.e. preparations intended for a local or regional effect on the skin. 

The Advanced Practical Medicinal Chemistry comprises of four major chapters that are intimately associated with specific emphasis on the synthesis of a hroad range of some t3T)ical and selected drugs commonly formd in the therapeutic armamentarium... 

The plasma or serum concentration (e.g. xgmL ) range within which the drug is likely to produce the therapeutic activity or effect. Table 1.1 provides, as an example, the therapeutic range of selected drugs. 

From calculations provided here, it is accurate to state that the failure to follow the dosage regimen (prescribed dose at a prescribed dosing interval) of a drug can result in serious consequences. Therefore, it is important that patients in your pharmacy, and/or a family member, follow the prescribed directions scmpulously, particularly for drugs that manifest a narrow therapeutic range and a long elimination half life. From your pharmacy experience, you may be aware that some patients tend to take selected... 

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