Selection, natural product drug

Selection Strategies for Plant-Based Natural Product Drug Discovery... 

An essential step in an efficient natural product drug discovery program is the judicious selection of an initial screening strategy. The in vitro methods available for anticancer drug discovery can be grouped into two major categories. These are the... 

The application areas for LC-MS, as will be illustrated later, are diverse, encompassing both qualitative and quantitative determinations of both high-and low-molecular-weight materials, including synthetic polymers, biopolymers, environmental pollutants, pharmaceutical compounds (drugs and their metabolites) and natural products. In essence, it is used for any compounds which are found in complex matrices for which HPLC is the separation method of choice and where the mass spectrometer provides the necessary selectivity and sensitivity to provide quantitative information and/or it provides structural information that cannot be obtained by using other detectors. 

Some of these natural products—and drugs made from them—are known collectively as the ergot alkaloids, and have found use in medicine. Ergonovine, for example, is a selective stimulant for contraction of uterine muscle and is used in conjunction with labor and delivery. A mixture of hydrogenated ergot alkaloids—reduced at the 9,10-position—has found... 

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