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Drug candidates selection

Ganter B, Tugendreich S, Pearson Cl, Ayanoglu E, Baumhueter S, Bostian KA, et al. Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. J Biotechnol 2005 119 219-44. [Pg.160]

Rapid physicochemical profiling as an aid to drug candidate selection. In ... [Pg.81]

The incorporation of in vitro metaboHsm data into allometric seating of compounds cleared by hepatic metabolism has been extensively evaluated [18] and shown to accurately predict human clearance. In this review it is suggested that the utility of such methods are most appropriately applied in drug candidate selection, to confirm early estimates and to support early clinical studies. [Pg.129]

Parrott, N., Jones, H., Paquereau, N. and Lave, T. (2005) Application of fidl physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man. Basic Clinical Pharmacology and Toxicology, 96, 193—199. [Pg.238]

Witte, I., Plappert, U de Wall, H. and Hartmann, A. (2007) Genetic toxicity assessment Employing the best science for human safety evaluation part III The comet assay as an alternative to in vitro clastogenicity tests for early drug candidate selection. Toxicological Sciences, 97, 21-26. [Pg.269]

L Millennium and Bayer Announce Genome-de-rived Oncology Drug Candidate Selected For First Human Studies, available online at http // www.mlnm.eom/news/2001/01-10-0.html, accessed on September 12,2002. [Pg.354]

This analysis scheme provided a quick measurement of binding affinity, and serves as a screening tool during drug candidate selection. Spreadsheets were constructed and used to calculate the binding affinity of the components. In the example described above, two incubation cycles followed by the SEC separation provided an enhancement of strong binders to weak binders. This LC/MS-based method provides a unique... [Pg.3424]

Balani SK, Miwa GT, Gan LS, et al. Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection. Curr Top Med Chem. 2005, 5(11) 1033-1038. [Pg.229]

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See also in sourсe #XX -- [ Pg.351 ]

See also in sourсe #XX -- [ Pg.27 ]



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Biopharmaceutics candidate drug selection

Candidate drug salt selection

Candidate drug selection biopharmaceutical support

Candidate drug selection lead identification

Candidate drug selection preformulation

Candidate drug selection, preferred

Candidate selection

Candidates

Candide

Drug discovery stages candidate selection

Drug selection

Selectivity, drug

Solubility candidate drug salt selection

Stability candidate drug salt selection

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