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Drug target selection

An example of drug target selection is the pairing of a G-protein coupled receptor, GPR-14, with its neuropeptide ligand, urotensin II, the most potent vasoconstrictor ever identified. GPR-14/urotensin II represents an attractive target for the treatment of disorders related to excessive... [Pg.59]

Identification of relevant drug targets, selection of drug receptor Q o Transgenic animals to probe complex in vivo systems, disease models... [Pg.171]

Muskus. (2010). Protein network prediction and topological analysis in Leishmania major as a tool for drug target selection. BMC Bioinformatics 11 4. ... [Pg.48]

The Jamieson paper reports the results of a number of studies, some successful, others not. Failures can be ascribed to the difficulties encountered in log P control. The first evident trouble concerns the choice of the lipophilicity descriptor many prefer log P, but this choice is questionable as has been outlined by Lombardo (see Chapter 16). Secondly, variations in lipophilicity profile influence not only hERG activity, but also target selectivity and also ADMET properties. Lipophilicity is a bulk property and its modification can involve different moieties of the molecules. Once the chemical modulation has been designed, but before moving to the bench, the research group should predict the consequences of this change on each step of the drug s action, but unfortunately this is not always done. [Pg.328]

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See also in sourсe #XX -- [ Pg.19 , Pg.20 , Pg.21 , Pg.22 , Pg.23 ]



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Drug selection

Drugs targeting

Selected Examples of Drug Action at some Common Target Areas

Selective targeting

Selectivity, drug

Target selection

Target selectivity

Target-selective drug design

Targeted drugs

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