Chemical formulas selected drugs

Exhibit 3.3 Chemical Formulas of some Selected Drugs... 

Drug class COX-2 selective inhibitor Chemical Structure see Figme 58.1 Chemical Formula Cj HigN O S molecular wt 370... 

Closures are composed of a polymer and include curing agents, activators, anti-oxidants, plasticizers, fillers and pigments within their formulae. They have to be selected with the drug product in mind to avoid chemical incompatibility and possible reaction with the ingredients in the product formulation. Sorption of the preservative from multiple-dose formulations has frequently been a problem and therefore closures may require saturation with the ingredients in the product prior to packaging. 

Celebrex (celecoxib) is a selective cyclooxygenase (COX)-2 inhibitor nonsteroidal anti-inflammatory drug chemically designated as 4- [5-(4-methylphenyl)-3- (trifluoromethyl) -1 -H-pyrazol-1 -yl)benzenesulfon-amide. It is a diaryl-substituted pyrazole with an empirical formula of Cj Hj FjNjO S and a molecular weight of 381.38. The potent anti-inflammatory effects of an original diarylheterocyclic compound, phenylbutazone, directed scientists to pharmacologically manipulate this chemical scaffold. As a result, celecoxib was the first of the coxibs to be introduced in 1999 by Searle/Pharmacia (now part of Pfizer Inc., USA) [1]. 

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