Hypoxia-selective cytotoxins drugs

The dinuclear dialkyldithiocarbamate precursor [Co2(dtc)5]+ reacted with diamine mustards N,N- and /V,/V -bis(2-chloroethyl)ethylenediamine (bee, dee) and their non-chlorinated analogs yield [Co(dtc)2(diamine)]+.1049 The bee and dee compounds were prepared and tested as potential hypoxia-selective cytotoxins, but did not prove of value as potential bioreductive anticancer drugs, partly due to their redox instability. 

Naylor MA, Stephens MA, Stratford IJ, Keohane A, O Neill P.Threadgill MD, Webb P, Fielden EM, Adams GE (1991) Aziridinyl nitropyrroles and nitropyrazoles as hypoxia-selective cytotoxins and radiosensitizers. Anti-Cancer Drug Design 6 151-167... 

W.R. Wilson, M. Tercel, R.F. Anderson and W.A. Denny, Radiation-activated prodrugs as hypoxia-selective cytotoxins model studies with nitroarylmethyl quaternary salts, Anti-Cancer Drug Des., 13 (1998)663. 

Quinoxaline 1,4-di-N-oxide derivatives were reported to exhibit hypoxia-selective cytotoxins [5,6] as well as myco-bacterium tuberculostatic activities [7,8]. From the spectrum of activities reported in the literature, combinations of the modifications at positions 2- and 5- of the molecule have provided the most active drugs. The ophmization of benzimidazole-based structures has resulted in various drugs that are prevalent in the market, such as omeprazole... 

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