Membranes drug design selectivity

However, in the very end both projects failed with respect to drug design The Hb ligands do not permeate the erythrocyte membrane, and the trimethoprim analogs lost the high selectivity for bacterial DHFRs. 

Early assessment of the ability of a drug candidate to penetrate the CNS is critical during the drug discovery selection process, especially for therapeutic indications that require delivery to a CNS site of action. Equally important is the ability to design drugs for non-CNS indications that have minimal brain penetration to avoid undesirable CNS side effects. In vitro BBB models using primary and immortalized brain capillary endothelial cells are described in the previous sections. The Ma-dine Darby canine kidney (MDCK) cell-line is increasingly used as a substitute for the more labor-intensive in vitro BBB models in passive permeability and membrane transport studies. 

The possibility of designing ion-selective channel formers, particularly when tissue selectivity based upon differing membrane lipid composition can be established, is an exciting challenge for future drug design. 

Ion-selective electrodes are widely used in pharmaceutical analysis. Numerous ion-selective electrodes based on poly(vinyl)chloride (PVC) have been constructed in order to determine various pharmacologically active substances in pharmaceutical preparations. The inherent advantages of ISE-s are simple design, construction and manipulation, reasonable selectivity, fast response time, low cost, adequate detection limit and adequate precision and accuracy. Therefore, the ISE potentiometric method is very attractive for pharmaceutical analysis. The first part of this chapter describes the properties and uses of PVC, as well as the general characteristics and preparation of the polymer membranes of ion-selective electrodes. The second part deals with the development of solid contact electrodes formed on non-crystal electrodes with a microporous matrix (e.g., vinyl polychloride dissolved in an appropriate modifier) selective for various nonsteroidal anti-inflammatory drugs (NSAlD-s) and their applications in pharmaceutical research. 

There are various ways in which CMEs can benefit analytical applications. These include acceleration of electron-transfer reactions, preferential accumulation, or selective membrane permeation. Such steps can impart higher selectivity, sensitivity, or stability to electrochemical devices. These analytical applications and improvements have been extensively reviewed (35-37). Many other important applications, including electrochromic display devices, controlled release of drugs, electrosynthesis, and corrosion protection, should also benefit from the rational design of electrode surfaces. 

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