Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Target-selective drug design

The Jamieson paper reports the results of a number of studies, some successful, others not. Failures can be ascribed to the difficulties encountered in log P control. The first evident trouble concerns the choice of the lipophilicity descriptor many prefer log P, but this choice is questionable as has been outlined by Lombardo (see Chapter 16). Secondly, variations in lipophilicity profile influence not only hERG activity, but also target selectivity and also ADMET properties. Lipophilicity is a bulk property and its modification can involve different moieties of the molecules. Once the chemical modulation has been designed, but before moving to the bench, the research group should predict the consequences of this change on each step of the drug s action, but unfortunately this is not always done. [Pg.328]

See other pages where Target-selective drug design is mentioned: [Pg.174]    [Pg.378]    [Pg.499]    [Pg.27]    [Pg.176]    [Pg.138]    [Pg.220]    [Pg.254]    [Pg.58]    [Pg.1130]    [Pg.2526]    [Pg.53]    [Pg.41]    [Pg.202]    [Pg.45]    [Pg.261]    [Pg.864]    [Pg.848]    [Pg.364]    [Pg.337]    [Pg.368]    [Pg.3]    [Pg.144]    [Pg.354]    [Pg.360]    [Pg.530]    [Pg.86]    [Pg.543]    [Pg.83]    [Pg.225]    [Pg.300]    [Pg.224]    [Pg.3]    [Pg.2]    [Pg.59]    [Pg.282]    [Pg.196]    [Pg.206]    [Pg.207]    [Pg.157]    [Pg.457]    [Pg.5]   


SEARCH



Drug design targets

Drug selection

Drug target selection

Drugs targeting

Selective design

Selective targeting

Selectivity, drug

Target selection

Target selectivity

Targeted drugs

© 2024 chempedia.info