Application of the Methodology to Selected Drugs

The oxidation of aminopyrene was particularly interesting in that new, hitherto-unobserved metabolites were detected. Variation of the reaction conditions then led to the 

It is useful to note that these are rare examples of porphyrin-mediated oxidation of sophisticated pharmaceutical entities. The reactions described above are generally applicable and have been used in our laboratories to achieve hydroxylation and N-demethylation on numerous other substrates. The hydroxy metabolite and the desmethyl derivative were usually difficult to synthesize by conventional organic chemistry methods. 

Krogsgaard-Larsen, R, Larsson, O. M. and Schousboe, A. GABA Mechanism in Epilepsy, 

Roberts, E. and Tower, D. B., Eds. GABA in Nervous System Function, Raven Press, 

Andersen, R, Dingledine, R., Gjerstad, L., Langmoen, LA. and Mosfeldt Laursen, A. J. Physiol., 

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