Selection drug factors

Selection of presumptive therapy considering every infected site Host factors Drug factors... 

The goal ofthe formulation scientist at this stage is to support the candidate selection process by understanding key physicochemical properties and other factors that can affect the delivery and exposure of compounds. Through well designed and executed formulation work, the formulation support helps to select drug candidates with appropriate physicochemical properties to ensure the developability... 

Several factors make H+, K+-ATPase a unique target for enzyme inhibition and provide a potential for selective drug targeting. Thus, the following factors most likely contribute to the highly specific action of omeprazole [3,4] ... 

Secondly, a possible beneficial role of COX-2 on the stomach should also be taken into account. In mice, COX-2 is expressed at the borders of gastric ulcers and has been implicated as a critical factor in promoting repair (11). Whether these experimental data have any clinical relevance is unknown, but this issue raises the possibility that individuals with pre-existing peptic ulcers who take COX-2 selective drugs may be at risk of delayed ulcer healing and potential complications. This issue may be of particular concern in patients with ulcers due to Helicobacter pylori infection. 

Given the multiple factors that alter drug disposition, measurement of the concentration in body fluids can assist in individualizing therapy with selected drugs. Determination of the concentration of a drug is particularly useful when well-defined criteria are met ... 

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