Lung Model Selection for Drug Absorption Studies

Lung Model Selection for Drug Absorption Studies 

Reduced screening capacity, increased expense and ethical issues 

Ex Vivo Isolated Perfused Lung The use of the IPL allows lung-specific pharmacokinetics to be investigated without the contribution of systemic ADME. In the IPL, the structural and cellular integrity of the lung tissue, the permeability barriers and interaction between different cell types and biochemical activity 

The development of combinatorial chemistry and high throughput screening programmes has stimulated efforts to find experimental and computational models to estimate and predict drug absorption, distribution, metabolism and elimination based on drug physicochemical properties. 

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