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Receptor-mediated

H2 The H2 receptor mediates effects, through an increase in cycHc adenosine monophosphate (cAMP), such as gastric acid... [Pg.139]

The principal organs involved in the peripheral clearance of hGH from the plasma are the kidney and fiver. hGH is cleared via glomerular filtration at the kidney and by a receptor-mediated mechanism at the fiver (58,59). In animal models, derivatives of hGH such as the 20,000 mol wt variant, oligomeric forms, and hGH complexed with GH-binding protein have been shown to be cleared from the semm at significandy lower rates than 22,000 mol wt hGH (60—62). The prolonged plasma half-life of these derivatives probably reflects a combination of decreased receptor affinity and size constraints on glomerular filtration. [Pg.198]

The class III cytokine receptor family includes two TNE receptors, the low affinity NGE receptor and 7-ceU surface recognition sites that appear to play a role in proliferation, apoptosis, and immunodeficiency. TNE-a (- 17, 000 protein) is produced by astrocytes and microglia and can induce fever, induce slow-wave sleep, reduce feeding, stimulate prostaglandin synthesis, stimulate corticotrophin-releasing factor and prolactin secretion, and reduce thyroid hormone secretion. TNE-a stimulates IL-1 release, is cytotoxic to oligodendrocytes, and reduces myelination this has been impHcated in multiple sclerosis and encephalomyelitis. Astrocyte TNE-a receptors mediate effects on IL-6 expression and augment astrocytic expression of MHC in response to other stimulants such as lEN-y. [Pg.539]

Calcium Channel Blockers. Because accumulation of calcium is one of the facets of the mote involved process leading to atherosclerosis, it would foUow that the antihypertensive calcium channel blockers might be effective in preventing atheroma. Both verapamil (Table 1) and nifedipine (Table 3) have been shown to stimulate the low density Upoprotein (LDL) receptor (159). This specific receptor-mediated pathway could theoretically improve Upid metaboUsm in the arterial wall, and thereby prove antiatherogenic. These effects have been proven in animals. [Pg.131]

Environmental estrogens estrogen receptor mediated Chlordecone... [Pg.51]

This review briefly summarises the available evidence on the relative potency of the phytoestrogens, and discusses the evidence that beneficial effects on human diseases may potentially arise from consumption of foodstuffs containing these compounds, with particular regard to those effects that have been suggested as possibly being related to the hormone-receptor mediated activities of the phytoestrogens. Certain causes for concern regarding these compounds are also addressed. [Pg.113]

In addition, isoquinolines have been used for receptor-mediated imaging and... [Pg.462]

They encapsulated poly(MA-CDA) into mannan-coated liposomes and evaluated superoxide production from mouse macrophages. The activity was three- to five-fold high compared with uncapsulated poly(MA-CDA) itself [5,11], suggesting that an increased incorporation of the polymer by the receptor-mediated endocytosis mediated the higher biological activity.. [Pg.179]

Recombinant systems can also be engineered to produce receptor-mediated responses by introducing adjunct proteins. For example, it has been shown that the Gal6 G-protein subunit couples universally to nearly all... [Pg.85]

FIGURE 7.3 Diversity of structures that interact with the (a) HIV reverse transcriptase inhibitor binding site [8] and (b) the CCR5 receptor mediating HIV-1 fusion [9],... [Pg.129]

Adenosine is produced by many tissues, mainly as a byproduct of ATP breakdown. It is released from neurons, glia and other cells, possibly through the operation of the membrane transport system. Its rate of production varies with the functional state of the tissue and it may play a role as an autocrine or paracrine mediator (e.g. controlling blood flow). The uptake of adenosine is blocked by dipyridamole, which has vasodilatory effects. The effects of adenosine are mediated by a group of G protein-coupled receptors (the Gi/o-coupled Ai- and A3 receptors, and the Gs-coupled A2a-/A2B receptors). Ai receptors can mediate vasoconstriction, block of cardiac atrioventricular conduction and reduction of force of contraction, bronchoconstriction, and inhibition of neurotransmitter release. A2 receptors mediate vasodilatation and are involved in the stimulation of nociceptive afferent neurons. A3 receptors mediate the release of mediators from mast cells. Methylxanthines (e.g. caffeine) function as antagonists of Ai and A2 receptors. Adenosine itself is used to terminate supraventricular tachycardia by intravenous bolus injection. [Pg.19]


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See also in sourсe #XX -- [ Pg.63 , Pg.65 , Pg.68 , Pg.69 , Pg.75 , Pg.79 ]




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Adenosine-receptor-mediated cardiac

Ah receptor-mediated toxicity

Antinociception delta receptor-mediated

Apoptosis death receptor-mediated pathway

Assay receptor mediated

Biological consequences of receptor-mediated endocytosis

Blood-brain barrier receptor-mediated transcytosis

Brain receptor mediated uptake systems

Calcium channels receptor-mediated activation

Cell function receptor-mediated covalent

Cell proliferation receptor-mediated

Chemokine-mediated migration receptors

Cholesterol receptor-mediated endocytosis

Classical Definition of Receptor-Mediated Functional Effects

Clearance receptor-mediated

Distribution receptor-mediated endocytosis

Drug absorption receptor-mediated endocytosis

Drug delivery systems receptor-mediated endocytosis

Endocytosis receptor-mediated

Endocytosis receptor-mediated ligand degradation

Enterocytes receptor-mediated endocytosis

Epidermal growth factor receptor mediated pathways, inhibition

Estrogen receptor-mediated signaling

Estrogen receptor-mediated signaling pathway

Extrinsic/receptor-mediated pathway

Fc receptor-mediated transcytosis

Fibre Sensors Without Chemical Receptors (Mediators)

Folate receptor mediated endocytosis

General features of receptor-mediated endocytosis

Glutamate receptor-mediated toxicity

Hormone Action Is Mediated by Receptors

Insulin receptor-mediated transcytosis

Lipoprotein receptor-mediated endocytosis

Lipoproteins receptor-mediated metabolism

Mannose receptor-mediated gene transfer

NMDA receptor-mediated responses

Neuronal receptors signaling mediated

Neuropeptide Y in sympathetic nerves evidence for Y1 receptor mediated vascular control

Neutrophils receptor-mediated signal transduction

Nuclear Receptor-Mediated Regulation of Drug Transporters

Phytoestrogens receptor mediated

Pinocytosis receptor-mediated

Platelet activating factor receptor-mediated activities

Potocytosis, receptor-mediated

Protein targeting receptor-mediated endocytosis

RHAMM (Receptor for hyaluronan mediated

Receptor mediated signaling pathways

Receptor-Mediated Effects

Receptor-Mediated Endocytosis and Drug Absorption

Receptor-mediated accumulation

Receptor-mediated delivery

Receptor-mediated endocytosi

Receptor-mediated endocytosis, and

Receptor-mediated genomic interactions

Receptor-mediated imaging

Receptor-mediated inflammatory

Receptor-mediated inflammatory process

Receptor-mediated inflammatory response

Receptor-mediated intracellular signalling

Receptor-mediated mechanisms

Receptor-mediated pathway

Receptor-mediated psychiatric symptoms

Receptor-mediated response

Receptor-mediated signal transduction

Receptor-mediated targeting

Receptor-mediated teratogenicity

Receptor-mediated toxicity

Receptor-mediated transcytosis

Receptor-mediated transport

Receptor-mediated transport system

Receptor-mediated transporters

Receptor-mediated transporters blood-brain barrier

Receptor-mediated uptake

Receptors for HA-mediated motility

Receptors for HA-mediated motility RHAMM)

Receptors of mediators

Regulation of receptor-mediated sterol uptake

Selective receptor mediation

Signaling receptor-mediated transduction

Silencing Mediator of Retinoid and Thyroid receptor

Silencing mediator for retinoid and thyroid receptors

Silencing mediator of retinoic acid and thyroid hormone receptor

Synapic potential mediation by non-NMDA receptors

Transferrin receptor-mediated endocytosis

Transient receptor potential channel mediators

Transport mechanisms receptor-mediated endocytosis

Tumor cells receptor-mediated endocytosis

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