Adenosine monophosphate ,

Nucleotides are phosphoric acid esters of nucleosides Those derived from adenosine of which adenosine 5 monophosphate (AMP) is but one example are especially promi nent AMP is a weak diprotic acid with s for ionization of 3 8 and 6 2 respectively In aqueous solution at pH 7 both OH groups of the P(0)(0H)2 unit are ionized... 

Therapeutic Function Vasodilator and platelet aggregation inhibitor Chemical Name Papaverine adenosine 5-monophosphate Common Name Papaverine adenylate... 

Draw the structure of adenosine 5 -monophosphate (AMP), an intermediate in some biochemical pathways. 

Adenosine-5 -monophosphate lanthanide complexes NMR, 3,1104 Adenosine phosphates metal complexes, 2, 977 6, 445 Adenosine 5 -triphosphate... 

C10H14N5O7PH2O Adenosine 5 -monophosphate, monohydrate (orthorhombic ADPOSM, 01 31 371... 

C15H11ClN3Pt+ C10H13N5O7P- -2.25 H20 Chloro(terpyridyl)platinum(Il)adenosine 5 -monophosphate, TPTAMP 43 373... 

Adenosine 5 -a,/ ,/ -triphosphate (pseudo ATP = T-ATP) was obtained by treatment of the phosphoric diimidazolide of adenosine 5 -monophosphate with tributylammonium phosphate. It rearranges with CDI into ATP.1511... 

RaitVK, Zhang Q,Fabris D,et al. Conversions of formaldehyde-modified 2 -deoxy-adenosine 5 -monophosphate in conditions modeling formalin-fixed tissue dehydration. I. Histochem. Cytochem. 2006 54 301-310. 

Figure 3.2 (a) The basic structure of a nucleotide, (b) The actual chemical structure of one representative nucleotide (adenylate, i.e. adenosine 5 -monophosphate)... 

Product distributions obtained on esterification of nucleosides and nucleotides under basic conditions throw further light on factors affecting selective reactivity. p-Toluenesulfonylation of adenosine 5 -monophosphate in aqueous alkali yielded exclusively (in 54-61% yield) the 2 -p-toluenesulfonate.107 Lack of reaction at HO-3 was attributed either to formation of a phosphoric p-toluenesulfonic anhydride, which sterically protected this hydroxyl group, or to the higher acidity of HO-2. It has been shown that the acidic site (with pKa 12.5) in adenosine is associated with the presence of both HO-2 and HO-3, as replacement of either of these by hydrogen, or of HO-2 by methoxyl, results in loss of this acidity.108 Inductive effects, or the sta-... 

Emission quenching is also observed with mononucleotides. In that case the quenching efficiency decreases from GMP (guanosine 5 monophosphate) to AMP (adenosine 5 monophosphate) i.e. it also follows the redox potentials of the bases, as G is more easily oxidisable than A, although the oxidation potential valura reported in the literature are rather different from one author to the other [101-104], Moreover the quenching rate constant by GMP in a Kries of different TAP and HAT complexes plotted versus the reduction potential of the excited state (Fig. 12) [95] is consistent with an electron transfer process. Indeed, as will be demonstrated in Sect. 4.3.1, these quenchings (by the mono-and polynucleotides) originate from such processes. 

Tissue electrodes [2, 3, 4, 5, 45,57], In these biosensors, a thin layer of tissue is attached to the internal sensor. The enzymic reactions taking place in the tissue liberate products sensed by the internal sensor. In the glutamine electrode [5, 45], a thick layer (about 0.05 mm) of porcine liver is used and in the adenosine-5 -monophosphate electrode [4], a layer of rabbit muscle tissue. In both cases, the ammonia gas probe is the indicator electrode. Various types of enzyme, bacterial and tissue electrodes were compared [2]. In an adenosine electrode a mixture of cells obtained from the outer (mucosal) side of a mouse small intestine was used [3j. The stability of all these electrodes increases in the presence of sodium azide in the solution that prevents bacterial decomposition of the tissue. In an electrode specific for the antidiuretic hormone [57], toad bladder is placed over the membrane of a sodium-sensitive glass electrode. In the presence of the antidiuretic hormone, sodium ions are transported through the bladder and the sodium electrode response depends on the hormone concentration. 

Nucleotides are named by adding a term denoting the number of phasphate groups (and their position) to the name of the nucleoside e.g. adenosine 5-monophosphate, AMP (or adenylate). In general, nucleotides are assumed to be ribonucleotides unless the prefix deoxy (or d- as abbreviation) is used. (See Figures 20.5 and 20.6)... 

The interactions between each of the stereoisomers of [(phen)2Ru(//-hat)Ru(phen)2]" " and GMP and adenosine-5 -monophosphate (AMP) have been investigated, and the effects on the photophysical properties of this complex of the presence of mono- and polynucleotides have been examined. Strong ion pairs are formed between [(phen)2Ru(//-hat)Ru(phen)2]" " and GMP or... 

This enzyme [EC 2.5.1.27], also called 2-isopentenyl-diphosphate AMP A -isopentenyltransferase and cyto-kinin synthase, catalyzes the reaction of AMP with A -isopentenyl diphosphate to yield pyrophosphate and A -(A -isopentenyl)adenosine 5 -monophosphate. 

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