Receptor-mediated targeting

Poste, G. (1984). Drug targeting in cancer therapy, in Receptor-Mediated Targeting of Drugs (G. Gregoriadis, G. Poste, J. 

G. Gregoriadis, J. Senior, B. Wolff, and C. Kirby, Fate of liposomes in vivo Control leading to targeting, in Receptor-Mediated Targeting of Drugs (G. Gregoriadis, G. Poste, J. Senior, and A. Trouet, eds.), Plenum Press, New York, 1984, p. 243. 

Fig. 11 Above Folate receptor-mediated targeting and SWNT-mediated delivery of structure 1 by endocytosis. Below. Structure 1. (Adapted from [60]).

Raso, V., and Basala, M. (1985) Study of the transferrin receptor using a cytotoxic human transferrin-ricin A chain conjugate. In Receptor-Mediated Targeting of Drugs, (G. Gregoriadis, ed.), Vol. 2, p. 73. Plenum, New York. 

C. M. Paulos, M. J. Turk, G. J. Breur, and P. S. Low. Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv. Drug Deliv. Rev. 56 1205-1217 (2004). 

S. M. Stephenson, P. S. Low, and R. J. Lee. Folate receptor-mediated targeting of liposomal drugs to cancer cells. Methods Enzymol. 387 33-50 (2004). 

Bot, A.I., D.J. Smith, S. Bot, L. Dellamary, T.E. Tarara, S. Harders, W. Phillips, J.G Weers, and C.M. Woods, Receptor-mediated targeting of spray-dried lipid particles coformulated with immunoglobulin and loaded with a prototype vaccine. Pharm Res, 2001.18(7) 971-9. 

Umamaheshwari, R.B., and N.K. Jain. 2004. Receptor-mediated targeting of lipobeads bearing acetohydroxamic acid for eradication of Helicobacter pylori. J Control Release 99 27. 

Gupta, A.K., et al. 2003. Receptor-mediated targeting of magnetic nanoparticles using insulin as a surface ligand to prevent endocytosis. IEEE Trans Nanobioscience 2 255. 

Umamaheshwari, R. B., and Jain, N. K. (2003), Receptor mediated targeting of lectin conjugated gliadin nanoparticles in the treatment of Helicobacter pylori, J. Drug Target., 11(7), 415—423 discussion 423-424. 

Poste, G. Receptor-Mediated Targeting of Drugs Gregor-iadis, G., Poste Senior, J.G., Trouet, J., Eds. Plenum Press New York, 1985 427-474. 

Site-specific controlled release following delivery to a target organ Release in response to requirements or feedback Receptor-mediated targeted drug delivery Type of drug delivery device... 

Raso, V. A. and Basala, M. (1984) Monoclonal antibodies as cell targeted carriers of covalently and non-covalently attached toxins, in Receptor Mediated Targeting of Drugs, vol. 82 (Gregoriadis, G., Post, G., Senior, J and Trouet, A., eds.), NATO Advanced Studies Institute, New York, pp. 119-138. 

From the above, it can be concluded that while capturing similar information with respect to size, hydrophobicity, polarizability, and perhaps hydrogen bonding, the 2-D and 3-D descriptor systems are likely to differ significantly in the type of information that can be extracted from QSAR modeling. Since the information redundancy is under 40% overall, it is advisable to employ both 2D-QSAR and 3D-QSAR methods when modeling receptor-mediated target properties. This combination of QSAR methods is illustrated in the next section. 

J. Farinas, A. Verkman, Receptor-mediated targeting of fluorescent probes in living cells,/. Biol. Chem. 1999, 274, 7603-7606. 

N. Brasseur, R. Langlois, C. La Madeleine, R. Ouellet, J.E. van Lier (1999). Receptor-mediated targeting of phthalocyanines to macrophages via covalent coupling to native or maleylated bovine serum albumin. Photochem. PhotobioL, 69, 345-352. 

Rihova B. Receptor-mediated targeted drug or toxin debvery. Adv Drug Del Rev 1998 29 273-289. 

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