Estrogen receptor-mediated signaling

The interaction of estrogen receptors with signaling systems of the cell membrane that respond to growth factors and mediate nongenomic, fast actions of estrogens will be reviewed as well. These mechanisms have a growing importance in the comprehension of phenomena like the induction of endothelial NOS (nitric oxide synthase) by estrogens (Rubanyi et al. 2002). 

Moriarty K, Kim KH, Bender JR. Estrogen receptor-mediated rapid signaling. Endocrinology 2006 147 5557-5563. 

Revankar, C.M., Cimino, D.F., Sklar, L.A., Arterburn, J.B. and Prossnitz, E.R. (2005) A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science, 307, 1625-1630. 

S. Kato, Estrogen receptor-mediated cross-talk with growth factor signaling pathways, Breast Cancer 2001, 8, 3-9. 

There is growing evidence on the existence of ERs anchored to specific regions of the plasmatic membrane of target cells. These receptors mediate fast actions of estrogens that are executed by their own signaling mechanisms and that are different from the actions used at the genome level by the intracellular receptors. 

Kharat, I. and F. Saatcioglu. Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p- dioxin are mediated by direct transcriptional interference with the liganded estrogen receptor. Cross-talk between aryl hydrocarbon- and estrogen-mediated signaling. J. Biol. Chem. 271 10533-10537, 1996. 

Font de Mora, J. and Brown, M. (2000) AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Molecular and Cellular Biology, 20, 5041-5047. 

Min, G., Kim, H., Bae, Y., Petz, L., and Kemper, J. K. (2002) Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching pi 60 coactivators.. /. Biol. Chem. Ill, 34626-34633. 

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