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Transduction, receptor-mediated signal

Figure 1. Simplified schematic of receptor-mediated signal transduction in neutrophils. Binding of ligand to the receptor activates a guanine-nucleotide-binding protein (G protein), which then stimulates phospholipase C. Phosphatidylinositol 4,5-bis-phosphate is cleaved to produce diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG stimulates protein kinase C. IP3 causes the release of Ca from intracellular stores, which results in an increase in the cytosolic Ca concentration. This increase in Ca may stimulate protein kinase C, calmodulin-dependent protein kinases, and phospholipase A2. Protein phosphorylation events are thought to be important in stimulating degranulation and oxidant production. In addition, ionic fluxes occur across the plasma membrane. It is possible that phospholipase A2 and ionic channels may be governed by G protein interactions. ... Figure 1. Simplified schematic of receptor-mediated signal transduction in neutrophils. Binding of ligand to the receptor activates a guanine-nucleotide-binding protein (G protein), which then stimulates phospholipase C. Phosphatidylinositol 4,5-bis-phosphate is cleaved to produce diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG stimulates protein kinase C. IP3 causes the release of Ca from intracellular stores, which results in an increase in the cytosolic Ca concentration. This increase in Ca may stimulate protein kinase C, calmodulin-dependent protein kinases, and phospholipase A2. Protein phosphorylation events are thought to be important in stimulating degranulation and oxidant production. In addition, ionic fluxes occur across the plasma membrane. It is possible that phospholipase A2 and ionic channels may be governed by G protein interactions. ...
Felder CC, Briley EM, Axelrod J, Simpson JT, Mackie K, Devane WA. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proc Natl Acad Sci USA 1993 90 7656-7660. [Pg.150]

Geng, Y. et al., Effects of nicotine on the immune response. I. Chronic exposure to nicotine impairs antigen receptor-mediated signal transduction in lymphocytes, Toxicol. Appl. Pharmacol., 135, 268-287, 1995. [Pg.539]

Diveu C, Venereau E, Froger J, et al Molecular and functional characterization of a soluble form of oncostatin M/interleukin-31 shared receptor. J Biol Chem 2006 281 36673-36682. Stress C, Radtke S, Clahsen T, et al Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism. J Biol Chem 2006 281 8458-8468. [Pg.91]

Rebois, R. V., and Hebert, T. E. (2003) Protein complexes involved in heptahelical receptor-mediated signal transduction. Receptors Channels. 9, 169-194. [Pg.100]

What do we know about receptor-mediated signalling pathways in parasitic platyhelminths Unfortunately, as a larger taxonomic group, we know very little. In-depth studies of the human blood fluke, 5. mansoni, have provided some of the most complete information on receptor-mediated signal transduction, and are summarized in the section on Transforming Growth Factor Receptor (TGFR) Pathway. ... [Pg.218]

Agonist-Directed Trafficking of 5-HT Receptor-Mediated Signal Transduction... [Pg.207]

Thomas EA, Carson MJ, Neal MJ, Sutcliffe JG. Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide. Proc Natl Acad Sci USA 1997 94 14,115-14,119. [Pg.531]

MEASUREMENT OF THE ACTIVITY OF RECEPTOR-MEDIATED SIGNAL TRANSDUCTION CASCADES... [Pg.219]

A77 1726, the active metabolite of Leflunomide does not block T-cell receptor-mediated signal transduction but its antiproliferative effects are antagonized by pyrimidine nucleosides. J. Heart Lung Transplant. 14,1016-1030. [Pg.203]

Nicholas MK, Lukas RV, Jafri NF, Faoro L, Salgia R (2006) Epidermal growth factor receptor -mediated signal transduction in thedevelopment and therapy of gliomas. Clin Cancer Res 12 7261-7270... [Pg.820]

Huzoor-Akbar, Wang, W., Kornhauser, R., Volker, C., and Stock, J.B. (1993). Protein prenylcysteine analog inhibits agonist-receptor-mediated signal transduction in human platelets. Proc Natl Acad Sci USA 90 868-872. [Pg.276]

Haugh JM. Localization of receptor-mediated signal transduction... [Pg.2092]

Haugh JM. Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing. Biophys. J. 2006 90 2297-2308. [Pg.2093]

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