Neuronal receptors signaling mediated

Tang T-S, Tu H, Chan EY, Maximov A, Wang Z, Wellington CL, Hayden MR, Bezprozvanny I (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(l,4,5) triphosphate receptor type 1. Neuron 39 227—239. 

Opioid receptors generally mediate neuronal inhibition. They couple to G or G0> and produce inhibition of Ca2+ channels and opening of K+ channels. They also inhibit adenylyl cyclase. Through this and other downstream signaling pathways, opioid receptors modulate... 

Da Prada, M. and Kellermann, O. (2006) Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells. FASEB Journal, 20 (11), 1843-1854. 

Whereas membrane-delimited actions occur within microdomains in the membrane, second messenger-mediated effects can occur over considerable distances. Finally, an important consequence of the involvement of G proteins in receptor signaling is that, in contrast to the brief effect of ionotropic receptors, the effects of metabotropic receptor activation can last tens of seconds to minutes. Metabotropic receptor predominate in the diffuse neuronal systems in the CNS (see below). 

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