Phytoestrogens receptor mediated

This review briefly summarises the available evidence on the relative potency of the phytoestrogens, and discusses the evidence that beneficial effects on human diseases may potentially arise from consumption of foodstuffs containing these compounds, with particular regard to those effects that have been suggested as possibly being related to the hormone-receptor mediated activities of the phytoestrogens. Certain causes for concern regarding these compounds are also addressed. 

Mechanisms of phytoestrogen action receptor and non-receptor mediated... 

There are considerable data on the chronic toxicity of NP in laboratory animals. The focus of these investigations has typically been evaluation of the potential reproductive and developmental effects of NP, due to its ability to modulate estrogen receptor-mediated responses. Many endpoints are not consistently observed across studies. Some of this variability may be due to differences in the conditions, design, and other test-specific variables of the toxicity tests. For example, since phytoestrogens are abundant in most laboratory animal feeds (such as found in soy and alfalfa) and are known to modulate estrogen receptor-mediated responses, phytoestrogens may be confounding factors as a result of the feed selection. 

Maggiolini, M. Bonofiglio,D. Marsico, S. 2001. Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol. Pharm. 60 595-602. 

Boyle C, Moizer K, Barlow T, Jeffery B, Paul S. Mechanisms of phytoestrogen action receptor and non-reeeptor mediated. 66-68 In Johnson I, Williamson G (eds). Phytochemical Functional Foods. 2003, CRC Press Ine, Florida, USA. 

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