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Glutamate receptor-mediated toxicity

Mydlineou C, Radcliffe P, Leonardi EK, Werner P, Olanow CW (1997) L-deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro. J Neurochem 68 33-39. [Pg.586]

Zeevalk GD, Nicklas WJ. 1990. Chemically induced hypoglycemia and anoxia Relationship to glutamate receptor-mediated toxicity in retina. J Pharmacol Exp Ther 253 1285-1292. [Pg.92]

Tacrolimus capacity to blockade NO pathway is weU demonstrated. NO plays a major role in the pathogenesis of cerebral hypoxia-ischemia injury mediated by glutamate/N-methyl-D-aspartate (NDMA). This injury depends on intracellular calcium influx through NDMA receptor channels, which activate calcineurin with consequent dephosphorylation of constitutive NO synthase (cNOS). Tacrohmus addition to cultured neuronal cells reduced NDMA-mediated toxicity, through the inhibition of calcineurin activation, inhibition of cNOS dephosphorylation and consequent decrease in... [Pg.647]

Marcaida G, Felipo V, Hermenegildo C, et al. 1992. Acute ammonia toxicity is mediated by the NMDA type of glutamate receptors. FEBS Lett 296(l) 67-68. [Pg.203]

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Glutamate receptors

Glutamate toxicity

Receptor-mediated

Toxicity, mediated

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