NMDA receptor-mediated response

Hampson AJ, Bornheim LM, Scanziani M, Yost CS, Gray AT, Hansen BM, Leonoudakis DJ, Bickler PE. (1998). Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission. J Neurochem. 70(2) 671-6. 

Martin G, Nie Z, Siggins GR. (1997). mu-Opioid receptors modulate NMDA receptor-mediated responses in nucleus accumbens neurons. J Neurosci. 17(1) 11-22. 

We demonstrated for the first time that crocin selectively antagonizes the inhibitory effect of ethanol on NMDA-receptor-mediated responses in hippocampal neurons. This action of crocin may underlie the antagonism against ethanol-induced memory impairment. Crocin should be useful as a new pharmacological tool for studying the mechanism of ethanol inhibition of NMDA receptor functions. 

Herrero, J. F., Headley, P. M., Parsons, C. G. Mementine selectively depresses NMDA receptor-mediated responses of rat spinal neurones in vivo, Neurosci. Lett. 1994, 165, 37-40. 

Kinney GG, Sur C, Burno M, Mallorga PJ, Williams JB, et al. 2003b. The glycine transporter type 1 inhibitor N-[3-(4 -fluorophenyl)-3-(4 -phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior. J Neurosci 23 7586-7591. 

Martina M, Gorfinkel Y, Halman S, Lowe JA, Periyalwar P, et al. 2004. Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in... 

Levine MS, Altemus KL, Cepeda C, Cromwell HC, Crawford C, Ariano MA, Drago J, Sibley DR, Westphal H (1996) Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1 A-deficient mutant mice. J Neurosci 75 5870-5882. 

Kombian SB, Malenka RC (1994) Simultaneous LTP of non-NMDA- and LTD of NMDA-receptor-mediated responses in the nucleus accumbens. Nature 368 242-246. 

ON Input As noted earlier, mitral/tufted cell apical dendrites respond to glutamate released from the ON via AMPA and NMDA receptors (Ennis et al., 1996, 2001 Aroniadou-Anderjaska et al., 1997 Chen and Shepherd 1997). The NMDA receptor-mediated response component is of unusually long duration, leading to a late spiking component in response to ON input (Ennis et al., 1996, 2001 Aroniadou-Anderjaska et al., 1997). An mGluR-mediated component of ON-evoked currents in mitral cells also occurs but is typically small under normal conditions (De Saint Jan and Westbrook, 2005 Ennis et al., 2006), yet, as will be discussed later, blockade of these receptors significantly alters ON-evoked spiking. 

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