Classical Definition of Receptor-Mediated Functional Effects

1 Classical Definitions of Receptor-Mediated Functional Effects 

2 Evolving Concepts of Receptor-Induced Functional Changes 

and Prusoff, W. H. Relationship between the inhibition constant (Kt) and the concentration of inhibitor which causes 50 percent inhibition (150) of an enzymatic reaction. Biochem. Pharmacol. 22, 3099-3108, 1973. This is one of the most commonly cited, and least read, papers in the field. 

Foreman, J. C., and Johansen, T. (Eds.). Textbook of Receptor Pharmacology, 2nd ed., CRC Press, Boca Raton, FL, 2003. 

Kenakin,T. A Pharmacology Primer Theory, Application and Methods. Elsevier, San Diego. 2004. 

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