Lead processing

Gillespie P, Goodnow RA Jr (2004) The hit-to-lead process in drug discovery. In Doherty A (ed) Annual reports in medicinal chemistry. Elsevier, Oxford, p 293... 

The objective of this volume is to provide an overview of the hit-to-lead process it is not intended to be all inclusive. Furthermore, much of the methodology described here is influenced by the culture of the authors respective institutions. In general, however, lead seeking approaches across industry (and academia) are more similar than they are different and are, for the most part, captured in this volume. 

The material inputs and pollution outputs resulting from primary and secondary lead processing are presented in Table 3.6. 

Primary lead processing activities usually result in air emissions, process wastes, and other solid-phase wastes. The primary air emissions from lead processing are substantial quantities of S02 and/... 

Conversion per pass is limited by reaction equilibrium after cooling to condense the product methanol, the unreacted gas is recycled to the reactor. Developed by Imperial Chemical Industries in the late 1960s, since when it has been the leading process. As of 1991, 41 plants had been commissioned and a further 7 were under contract or construction. 

Preparation. Thallium is recovered as by-product of zinc and lead processes. 

Luinstra, E. 1996. Hydrogen from H S a review of the leading processes. Proceedings of 7th GRI Sulfur Recovery Conference, Gas Research Institute, Chicago, pp. 149-165. 

Goodnow, R.A., Jr, Gillespie, P., Bleicher, K. Chemoinformatic tools for library design and the hit-to-lead process a user s perspective. In Chemoinformatics in Drug Discovery, Oprea, T.I. (ed.) Wiley-VCH, Weinheim, 2004, 381-435. 

Alanine, A., Nettekoven, M., Roberts, E., and Thoma, A.W. Lead generation - enhancing the success of dmg discovery by investing in the hit to lead process. Comb. Chem. High Throughput Screen. 2003, 6, 51-66. 

Chemoinformatic Tools for Library Design and the Hit-to-Lead Process A User s Perspective... 

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