Receptor-mediated imaging

In addition, isoquinolines have been used for receptor-mediated imaging and... 

BREEMAN, W.A.P., et al., Somatostatin receptor-mediated imaging and therapy Basic science, current knowledge, limitations and future perspectives, Eur. J. Nucl. Med. 28 (2001) 1421-1429. 

S. M., Hong, S.S., Miller, D.D. and Dalton, J.T. (2006) Predinical pharmacology of a nonsteroidal ligand for androgen receptor-mediated imaging of prostate cancer. The Journal of Pharmacology and Experimental Therapeutics, 317, 402 108. 

Kahn, M.G.C. Konde, E. Dossou, R Labaree, D.C. Hochberg, R.B. Hoyte, R.M. Microwave-enhanced nucleophilic fluorination in the synthesis of fluoropyridyl derivatives of [3,2-c]pyrazolo-corticosteroids, potential glucocorticoid receptor-mediated imaging agents. Bioorg. Med. Chem. Lett. 2006, 16, 3454-3458. 

Yang, J, Chen, H, Vlahov, I. R, Cheng, J. X. and Low, P. S. (2006a). Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging. Proc. Natl. Acad. Sci. USA 103, 13872-13877. 

C. M. Paulos, M. J. Turk, G. J. Breur, and P. S. Low. Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv. Drug Deliv. Rev. 56 1205-1217 (2004). 

Although not yet proven, it is likely that receptor-mediated endocytosis occurs with a number of systems in which the imaging Gd-probes are linked either to peptides as targeting vectors that bind to specific receptors or to nutrient or pseudo-nutrient moieties that interact with the proper transporter up-regulated in tumor cells. 

Vibrational imaging of living cells has been applied for studying intracellular lipid droplet organelles [86, 89, 90, 113, 114] (cf. Fig. 6.10A), monitoring receptor-mediated endocytosis [92], analyzing mouse embryonic stem cells... 

Y. Lill, K. L. Martinez, M. Lill, B. H. Meyer, H. Vogel and B. Hecht, Kinetics of the initial steps of G-protein coupled receptor mediated cellular signaling revealed by single molecule imaging, Chem. Phys. Chem. 6, 1633 (2005). 

The nanoparticles can be incorporated into cells by incubation the nanoparticies suspended in DMEM medium with the cells for 12 to 48 hours. From dark field light scattering imaging [54], it has been established that gold nanoparticies are taken intracellulariy into these cell lines. The nanoparticies are accumulated inside cytoplasm of live cells by receptor-mediated endocytosis processes. Figure 20.16 shows that for most of samples gold nanospheres quench the protein fluorescoice at 12 h incubation time. However, in some samples fluorescence enhancement is observed. 

UGUR, O., et al., Ga-66 labelled somatostatin analogue DOTA-Dphe -Tyr3-octreotide as a potential agent for positron emission tomography imaging and receptor mediated internal radiotherapy of somatostatin receptor positive tumours, Nucl. Med. Biol. 29 (2002) 147-157. 

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