Receptor-mediated delivery

Wagner E, Ogris M, Zauner W (1998) Polylysine-based transfection systems utilizing receptor-mediated delivery. Adv Drug Deliv Rev 30 97-113... 

Versluis, A.J., PC. Rensen, E.T. Rump, T.J. Van Berkel, and M.K. Bijsterbosch, Low-density lipoprotein receptor-mediated delivery of a lipophilic daunorubicin derivative to B16 tumours in mice using apolipoprotein E-enriched liposomes. Br J Cancer, 1998. 78(12) 1607-14. 

Vinogradov, S., Batrakova, E., Li, S. and Kabanov, A. (1999a) Polyion complex micelles with protein-modified corona for receptor-mediated delivery of oligonucleotides into cells. Bioconjug. Chem., 10, 851-860. 

A. Mukhopadhyay, B. Mukhopadhyay, R.K. Srivastava and S.K. Basu, Scavenger-receptor mediated delivery of daunomycin elicits selective toxicity towards neoplastic cells of macrophage lineage, Biochem. J. 284 (1992) 237-241. 

B. Mukhopadhyay, A. Mukhopadhyay and S.K. Basu, Enhancement of tumouricidal activity of daunomycin by receptor-mediated delivery in vivo studies, Biochem. Pharmacol. 46 (1993) 919-924. 

R. J. Fallon and A. L. Schwartz, Receptor-mediated delivery of drugs to hepato-cytes, Adv. Drug Deliv. Rev. 4 49-65 (1989). 

Feero WG, Rosenblatt JD, Sirianni N, Morgan JE, Partridge TA, Huang L, Hoffman EP, Selection and use of ligands for receptor-mediated delivery to myogenic cells, Gene. Ther., 4(7) 664-674, 1997. 

Gotten, M., Wagner, E., Zatloukal, K., Phihips, S., Curiel, D.T., and Bimstiel, M.L. (1992). High-efficiency receptor-mediated delivery of small and large (48 kilobase) gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. Proc. Natl. Acad. Sci. USA 89, 6094 6098. 

Huwyler, J., Yang, J., and Pardridge, W. M. (1997) Receptor mediated delivery of daunomycin using immunoliposomes pharmacokinetics and tissue distribution in the rat. The Journal of Pharmacology and Experimental Therapeutics, 282, 1541-1546. 

As far as HDL levels and metabolism are concerned, one result of the LCAT- and transfer protein-catalyzed reactions is the production of a dynamic spectrum of particles with a wide range of sizes and lipid compositions (Chapter 19). Nascent HDL particles contain mostly apo A1 and phospholipids, and undergo modulation and maturation in the circulation. For instance, the unesterified cholesterol incorporated into plasma HDL is converted to cholesteryl esters by LCAT, creating a concentration gradient of cholesterol between HDL and cell membranes, which is required for efficient cholesterol efflux from cells to HDL. In addition, cholesteryl ester transfer protein transfers a significant amount of HDL cholesteryl ester to VLDL, IDL, and LDL for further transport, primarily to the liver. Thus, a substantial fraction of cell-derived cholesterol is delivered as part of HDL indirectly to the liver via hepatic endocytic receptors for IDL and LDL this process is termed reverse cholesterol transport . However, receptor-mediated delivery of HDL cholesterol to cells is fundamentally different from the classic LDL receptor-mediated endocytic pathway, as described in Section 7.3.2. 

Receptor-Mediated Delivery of Proteins and Peptides to Tumors... 

Zhang K, Wang Q, Xie Y, Mor G, Sega E, Low PS, et al. Receptor-mediated delivery of siRNAs by tethered nucleic acid base-paired interactions. RNA 2008 14 577-583. 

There is more work in this area, but most of it revolves around the development of PNIPAM-stabilized lipid/polymer hybrid liposomes for drag delivery and receptor-mediated delivery of these liposomes to cells. " Both of these topics are outside the scope of this review. 

Eisele K, Gropeanu R, Musante A et al (2010) Tailored albumin-based copolymers for receptor-mediated delivery of perylenediimide guest molecules. Macromol Rapid Commun 31 1501-1508. doi 10.1002/marc.201000176... 

Bharali DJ, Lucey DW, Jayakumar H, Pudavar HE, Prasad PN (2(K)5) Folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy. J Am Chem Soc 127 11364... 

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