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Cellular retinoic acid binding proteins gene targeting

Vitamin A absorbs UV light between 300 and 350 nm. After acute exposure to UVA or UVB a dose-dependent decrease of vitamin A was shown in mouse59 and humans.84 UV irradiation markedly reduced mRNA and protein of the nuclear retinoid receptors RARy and RXRa in humans and led to a near loss of retinoic acid induction of the RAR/RXR target genes and the cellular retinoic acid binding protein II thus effectively causing additionally a functional vitamin A deficiency.85... [Pg.381]

Gene targeting in embryonic stem (ES) cells is a powerful technique for the modification of the mouse genome (1-3). Regarding the retinoid receptors, a number of laboratories have reported the phenotype of mice in which a given retinoic acid receptor (RAR) or retinoid X receptor (RXR) has been inactivated by this technique (4-12). In addition, a number of cellular retmoid-binding protein-null mice have also been generated (13-15). [Pg.405]

See other pages where Cellular retinoic acid binding proteins gene targeting is mentioned: [Pg.380]    [Pg.369]    [Pg.441]    [Pg.326]    [Pg.166]    [Pg.449]    [Pg.86]    [Pg.417]    [Pg.993]   
See also in sourсe #XX -- [ Pg.411 ]



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Cellular retinoic acid binding proteins

Cellular targets

Gene targeting

Protein target

Protein targeting

Protein targeting proteins)

Proteins targeted

Retinoic

Retinoic acid

Retinoic acid binding protein

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