Peroxisomes, protein targeting signals matrix proteins

Both the integral membrane proteins of peroxisomes as well as the peroxisomal matrix proteins are synthesised on free polyribosomes and are specifically targeted to peroxisomes via dedicated peroxisomal targeting signals. The biogenesis of peroxisomes follows a sequential pattern, which involves first the insertion of peroxisomal membrane proteins into the membrane of the pre-peroxisomal structure, derived from the endoplasmic reticulum, followed by insertion of the various matrix proteins. 

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