Non-Protein Kinases as Therapeutic Targets

JEROEN C. VERHEIJEN a, DAVID J. RICHARDb AND ARIE ZASKC 

We will discuss small molecule inhibitors of three main classes of nonprotein kinases sugar kinases, nucleoside kinases and lipid kinases. This chapter will be limited to discussion of the inhibition of human kinases. Several non-human non-protein kinases have been the focus of drug development efforts as well, including choline kinase for inhibition of Plasmodium, uridine-cytidine kinase as an anti-parasitic target and thymidine kinase inhibitors as an anti-mycobacterial treatment or for treatment of Herpes simplex viral infections. These applications will not be discussed in this chapter. Peptide 

RSC Drug Discovery Series No. 19 Kinase Drug Discovery 

Edited by Richard A. Ward and Frederick Goldberg Royal Society of Chemistry 2012 

Due to the large number of non-protein kinases as potential drug development targets, this chapter does not provide an exhaustive review of all efforts in this field, but rather provides the reader with a sampling of representative examples and leading references, with a focus on some of the more recent drug development efforts. 

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