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Protein kinases inhibitors/drug targets

Akritopoulou-Zanze I (2006) The identification of new protein kinase inhibitors as targets in modern drug discovery. ID rugs 9 481-487... [Pg.1012]

Organometallic Protein Kinase Inhibitors 3.1 Protein Kinases as Drug Targets... [Pg.146]

Daub, H., K. Specht, and A. Ullrich. 2004. Strategies to overcome resistance to targeted protein kinase inhibitors. Nat. Rev. Drug Discov. 3, 1001-1010. [Pg.22]

Selectivity is critical for the use of protein kinase inhibitors in basic research. Protein kinases are a large class of enzymes related by sequence, aU of which share the common capacity to bind ATP (1). Most inhibitors developed to date are competitive with ATP and bind in the active site. Thus, the potential for inhibitor cross-reactivity is great. Hence, estabhshing whether drug effects are caused by actions on the expected target or to... [Pg.1130]


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Drug kinase inhibitors

Drug targets, protein kinases

Drugs targeting

Kinase inhibitors

Kinase, kinases inhibitors

Kinases targeting

Protein drugs

Protein inhibitor

Protein kinase inhibitors

Protein target

Protein targeting

Protein targeting proteins)

Proteins targeted

Targeted drugs

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