Organophosphorous compound

Fest, C. and Schmidt, K.-J. (1982). Chemistry of Organophosphorous Compounds. Second edition, Berlin Springer-Verlag. 

Greig-Smith, P.W., Walker, C.H., and Thompson, H.M. (1992). Ecotoxicological consequences of interactions between avian esterases and organophosphorous compound. In B. BaUantyne and T.C. Marrs (Eds.) (1992). Clinical and Experimental Toxicology of Organophosphates and Carbamates, 295-304. Oxford, U.K. Butterworth-Heinemann. 

Richards, R, Johnson, M., Ray, D., and Walker, C.H. (1999). Novel protein targets for organophosphorous compounds. In Esterases Reacting with Organophosphorous Compounds. E. Reiner, V. Simeon-Rudolf, and B.P. Doctor et al. (Eds.) Special Issue of Chemico-Biological Interactions 119-120. 

Walker, C.H. (1989). The development of an improved system of nomenclature and classification of esterases. In E. Reiner, W.N. Aldridge, and F.C.G. Hoskin (Eds.) Enzymes Elydrolysing Organophosphorous Compounds, Chichester Ellis Harwood. 53-64. 

Ahern et al. [386] has observed that organophosphorous compounds are coprecipitated with cobalt and pyrrolidine dithiocarbonate, and suggest that this might be a suitable means of preconcentrating the phosphorus fraction of harbour water prior to analysis by X-ray fluorescence spectrometry. 

Organophosphorous Compound Containing elements of phosphorous and carbon, the physiological effects of such a compound include inhibition of acetylcholinesterase. A number of pesticides including parathion and malathione, and virtually all nerve agents, are organophosphorous compounds. 

Chemical Family Sulfonated organophosphorous compound Formula/Chemical Structure ... 

Abou-Donia MB, Lapadula DM, Suwita E. 1988. Cytoskeletal proteins as targets for organophosphorous compound and aliphatic hexacarbon-induced neurotoxicity. Toxicology 49 469-477. 

Allylphosphonium salts are synthesized by substitution of allyl halides with PPh3. The use of allyl alcohol, allyl acetate, or nitropropene with a palladium catalyst has also been reported.19 It is shown in this study that the organophosphorous compounds can be obtained by a palladium-catalyzed addition to an allene. A notable aspect of this method is that it can control the stereochemistry of the phosphonium salt, and that (Z)-allylphosphonium salts have been obtained in pure form for the first time. 

Phosphonium salts can be synthesized from unsaturated compounds by addition of a triarylphosphine and an acid in the presence of a palladium or rhodium catalyst. Transition metal catalysis turned out to be effective for the synthesis of organophosphorous compounds. 

M. K. Johnson, P. Glynn, Active-Site Labelling and Purification of Neuropathy Target Esterase (NTE) Using a Biotinylated Organophosphorous Compound , Toxicologist 1993, 73,211. 

Organophosphates The second class of cholinesterase inhibitors is made up of organophosphorous compounds with the general formula ... 

Organophosphorous compounds act by forming a complex with the hydroxyl group of serine of the cholinesterase enzyme, thus forming a covalent bond with the phosphorous atom. 

Currently, there are a number of organophosphorous compounds used in everyday life and agriculture as insecticides. Many of them are lipid-soluble compounds that are quickly and completely absorbed in practically every way, including skin as well as respiratory and... 

Metrifonate is an organophosphorous compound that is effective only in the treatment of S. haematobium The active metabolite, dichlorvos, inactivates acetylcholinesterase and potentiates inhibitory cholinergic effects. The schistosomes are swept away from the bladder to the lungs and are trapped. Therapeutic doses produce no untoward side effects except for mild cholinergic symptoms. It is contraindicated in pregnancy, previous insecticide exposure, or with depolarizing neuromuscular blockers. Metrifonate is not available in the United States. 

Organophosphorous compounds have also been used as nucleophiles with unsaturated oxazolones. Initially, Michael reaction of a trialkyl- or dialkylphosphite gives 617 or 619 that undergo subsequent ring opening to yield a 2-acylamino-3-phosphonyl-618 or 2-acylammo-3-phosphinyl-620 derivative of the corresponding carboxylic acid, respectively (Scheme 7.198). ° ... 

Aliphatic Organophosphorous Compounds Aliphatic Organophosphorous Compounds Dibutyl Phosphate Tributyl Phosphate Alkanes and Cyclic Alkanes Alkanes and Cyclic Alkanes Cyclohexane Decane, n Fieptanes Fiexadecane Fiexanes... 

Aromatic Nitro Compounds with Other Functional Groups Aromatic Nitro Compounds with Other Functional Groups Pentachloronitrobenzene Aromatic Organophosphorous Compounds Aromatic Organophosphorous Compounds Parathion... 

Dibutyl Phosphate under Aliphatic Organophosphorous Compounds... 

Organophosphorous Compounds under Organophosphorus Compounds Organosulfur Compounds with Other Eunctional Groups Other Nitrophenols... 

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