Functional targets Proteins

In the event that no partial DNA sequences are known, but functional target protein is available, we can identify the terminal amino acid sequence. The three-to-... 

In view of the importance of the motor dynein for microtubular function, this protein is currently considered as a new target for the development of cytostatic agents. 

Rapamycin is an immunosuppressive diug and an inhibitor of S6K1 (also known as p70S6-kinase) which phosphorylates ribosomal S6 protein. S6K1 is activated in response to insulin via activation of Akt. Rapamycin binds to a specific target protein (mTOR, mammalian target of rapamycin) which is functionally located downstream of Akt, but upstream... 

Early work on 14-3-3 proteins placed researchers in a peculiar position of trying to define the precise function of 14-3-3s. This came from the large number of, and apparently diverse type of targets proteins. Continued work has brought more and more insights and it is... 

The development of protein chip assays to determine protein function using purified components is a rapidly advancing area. Automated systems for the assay of protein function on chips in parallel for thousands of proteins simultaneously will likely be available in the next few years. These miniaturized arrays will be useful for basic research as well as for diagnostics and drug development. For instance, the combination of protein chips with combinatorial chemistry will allow the simultaneous screening of vast collections of small molecules against vast collections of potential target proteins. 

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