Drug targets, protein kinases

Daub, H., K. Specht, and A. Ullrich. 2004. Strategies to overcome resistance to targeted protein kinase inhibitors. Nat. Rev. Drug Discov. 3, 1001-1010. 

This was the first time that a drug-insensitive protein kinase was used for the purpose of drug target validation. Eyers et al. also discussed the general applicability to the study of other protein kinases [50], as is described in the next section. 

Almost half of the fragment-derived drugs that have entered the clinic target protein kinases. This reflects both the recent popularity of this class of targets [99] as well... 

Chico, L.K., Van Eldik, L.J., Watterson, D.M. (2009). Targeting protein kinases in central nervous system disorders. Nature Reviews Drug Discovery, 8, 892-909. 

Doerig, C. and Meijer, L. (2007) Antimalarial drug discovery targeting protein kinases. Expert Opin. Ther. Targets, 11,279-290. 

Hardie DG (2007) AMP-Activated Protein Kinase as a Drug Target. Annu Rev Pharmacol Toxicol 47 185-210... 

Akritopoulou-Zanze I (2006) The identification of new protein kinase inhibitors as targets in modern drug discovery. ID rugs 9 481-487... 

Caponigro F, French RC, Kaye SB (1997) Protein kinase C a worthwhile target for anticancer drugs Anticancer Drugs 8(l) 26-33... 

Finally, development of drugs targeted toward modification of kinases and phosphatases required for activation or inhibition of particular transcription factors is a promising therapeutic approach. The problem with this paradigm is the specificity of the kinases and phosphatases, since they will often act enzymatically on multiple proteins (see Chs 24 and 25). Furthermore, such drugs often lack specificity and may interact with multiple kinases or phosphatases. 

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