Nonobese diabetic

Signaling pathways. (From Bahjat, F.R., Characterization and Genetic Analysis of the Resistance of Nonobese Diabetic Mice to Tumor Necrosis Factor-Alpha Mediated Hepatocyte Apoptosis and Lethality, A dissertation presented to the Graduate School of the University of Florida in partial fulfillment of the requirement for the degree of doctor of philosophy. University of Florida, 2002. Reproduced with permission.)... 

Masteller EL, Warner MR, Tang Q, Tarbell KV, McDevitt H, Bluestone JA Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice. J Immunol 2005 175 3053-3059. 

Chang CL, Chang SL, Lee YM, Chnang DY, Kuo HK, Yang W C. (2007) Cytopiloyne, a polyacetylenic glncoside, prevents type 1 diabetes in nonobese diabetic mice. //rnmnno/178 6984-6993. 

Heineke, E. W., Johnson, M. B., Dillberger, J. E., and Robinson, K. M. (1993). Antioxidant MDL 29,311 prevents diabetes in nonobese diabetic and multiple low-dose STZ-injected mice. Diabetes 42, 1721-1730. 

Maki, T., Ichikawa, T., Blanco, R., and Porter, J. (1992). Long-term abrogation of autoimmune diabetes in nonobese diabetic mice by immunotherapy with anti-lymphocyte serum. Proc. Natl. Acad. Sci. U.S.A. 89, 3434-3438. 

Sempe, P., Bedossa, P., Richard, M.-F., Villa, M.-C., Bach, J.-F., and Boitard, C. (1991). Anti-a/b T cell receptor monocU)nal antibody provides an efficient therapy for autoimmune diabetes in nonobese diabetic (NOD) mice. Eur. J. Immunol 21, 1163-1169. 

Shizuru, J. A., Taylor-Edwards, C., Banks, B. A., Gregory, A. K., and Fathman, C. G. (1988). Immunotherapy of the nonobese diabetic mouse Treatment with an antibody to T-helper lymphocytes. Science 240, 659-662. 

Wicker, L. S., Miller, B. J., and Mullen, Y. (1986). Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 35,855-860. 

Models of autoimmune diabetes in nonobese diabetic mice (NOD) mice, insulin-dependent diabetes, and experimental allergic encephalyomyelitis (EAE) were also used to evaluate naked pDNA therapy. In the latter models, a predominant Thl cytokine response is thought to play a role in disease symptoms and etiology. Treatment of these mouse models with a TH2 type cytokine, such as IL-10 or IL-4, has been found to shift the immune response and lessen the severity of disease. Therefore, the efficacy of pDNA delivery of a Th2 cytokine was explored in these specific models. 

Nitta, Y., Tashiro, F., Tokui, M., Shimada, A., Takei, I., Tabayahsi, K. and Miyazaki, J.-I. (1998) Systemic delivery of interleukin-10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice. Hum. Gene Then, 9,1701-1707. 

The nonobese diabetic mouse (NOD), as well as the biobreeding (BB) rats are the two rodent models whose diabetes-related immunopathology is considered to be quite similar to that in humans. Studies in these animal models have revealed that autoreactive T cells that mediate islet 8 cell destruction belong to the Thl subset of T cells (produce IL-2 and IFN-7), whereas regulatory T cells are of the Th2 type (produce IL-4 and IL-10). Because Thl and Th2 cells are mutually inhibitory, there have been many trials using IL-4 and/or IL-10 for the prevention of autoimmune disease, like autoimmune diabetes, rheumatoid arthritis (Evans et al., 1996 Boyle et al., 1999), and inflammatory bowel disease (Rogy et al., 2000). 

Faust A, Rothe, H., Schade, U., Lampeter, E. and Kolb, H. (1996) Primary nonfunction of islet grafts in autoimmune diabetic nonobese diabetic mice is prevented by treatment with interleukin-4 and interleukin-10. Transplantation, 62, 648-652. 

Jacob, C.O., Asiso, S., Michie, S.A., McDevitt, H.O. and Acha-Orbea, H. (1990) Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF) similarities between TNF-a and interleukin 1. Proc. Natl. Acad. Sci. USA, 87, 968-972. 

Moritani, M., Yoshimoto, K., li, S., Kondo, M., Iwahana, El., Yamaoka, T. et al. (1996) Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Thl lymphocytes. J. Clin. Invest., 98, 1851-1859. 

Mueller, R., Krahl, T. and Sarvetnick, N. (1996) Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med., 184,1093-1099. 

Pennline, K.J., Roque-Gaffney, E. and Monahan, M. (1994) Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin. Immunol. Immuno-pathol., 71,169-175. 

Piccirillo, C.A., Chang, Y. and Prud homme, G.J. (1998) TGF-/ 1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice. J. Immunol., 161, 3950-3956. 

Rapoport, M.J., Jaramillo, A., Zipris, D., Lazarus, A.H., Serreze, D.V., Leiter, E.H. etal. (1993) Interleukin4 reverse T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med., 178, 87-99. 

He CJ, Zheng F, Stitt A, Striker L, Hattori M, Vlassara H. 2000. Differential expression of renal AGE-receptor genes in NOD mice possible role in nonobese diabetic renal disease. Kidney Int 58(5) 1931—1940. 

Singer, S. M., Tisch, R., Yang, X. -D. and McDevitt, H. O. (1993) An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells. Proc. Natl. Acad. Sci. USA 90, 9566-9570. 

Lieberman, S. M., Takaki, T., Han, B., San-tamaria, P., Serreze, D. V., et al. (2004) Individual nonobese diabetic mice exhibit unique patterns of CD 8 T cell reactivity to three islet antigens including the newly identified widely expressed dystrophia myotonica kinase./. Immunol. 173, 6727-6734. 

Prevention of type 1 diabetes in nonobese diabetic mice by allogeneic bone marrow transplantation. Proc. Natl. Acad. Sci. USA 82, 7743-7747. 

Li, H., Kaufman, C. L., Boggs, S. S., Johnson, P. C., Patrene, K. D., et al. (1996) Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulins in nonobese diabetic (NOD) mice. J. Immunol. 156, 380-388. 

Cameron, M. J., Arreaza, G. A., Zucker, P., Chensue, S. W., Strieter, R. M., Chakrabarti, S. and Delovitch, T. L. (1997). IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. J. Immunol. 159, 4686-4692. 

Di Lorenzo, T. P., Graser, R. T., Ono, T., Christianson, G. J., Chapman, H. D., Roopenian, D. C., Nathenson, S. G. and Serreze, D. V. (1998). Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement. Proc. Natl. Acad. Sci. USA 95, 12538-12543. 

Gallichan, W. S., Balasa, B., Davies, J. D. and Sarvetnick, N. (1999). Pancreatic IL-4 expression results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse. J. Immunol. 163, 1696-1703. 

Hunger, R. E., Muller, S., Laissue, J. A., Hess, M. W., Carnaud, C., Garcia, I. and Mueller, C. (1996). Inhibition of submandibular and lacrimal gland infiltration in nonobese diabetic mice by transgenic expression of soluble TNF-receptor p55. J. Clin. Invest. 98, 954-961. 

Nagata, M., Santamaria, P., Kawamura, T., Utsugi, T. and Yoon, J. W. (1994). Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice. J. Immunol. 152, 2042-2050. 

Oldstone, M. B. (1988). Prevention of type I diabetes in nonobese diabetic mice by virus infection. Science 239, 500-502. 

Parishes, N. M., Chandler, P., Quartey-Papafio, R., Simpson, E. and Cooke, A. (1993). The effect of bone marrow and thymus chimerism between nonobese diabetic (NOD) and NOD-E transgenic mice, on the expression and prevention of diabetes. Eur. J. Immunol. 23, 2667-2675. 

Rabinovitch, A., Suarez-Pinzon, W. L., Sorensen, O., Bleackley, R. C., Power, R. F. and Rajotte, R. V. (1995). Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice. Analysis of cytokine mRNA expression in the graft.Transplantation 60, 368-374. 

Verdaguer, J., Yoon, J. W., Anderson, B., Averill, N., Utsugi, T., Park, B. J. and Santamaria, P. (1996). Acceleration of spontaneous diabetes in TCR-beta-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+ T cells... 

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