Apoptosis hepatocyte

Signaling pathways. (From Bahjat, F.R., Characterization and Genetic Analysis of the Resistance of Nonobese Diabetic Mice to Tumor Necrosis Factor-Alpha Mediated Hepatocyte Apoptosis and Lethality, A dissertation presented to the Graduate School of the University of Florida in partial fulfillment of the requirement for the degree of doctor of philosophy. University of Florida, 2002. Reproduced with permission.)... 

Guicdardi, M.E., Deussing, J., Miyoshi, H., Bronk, S.F., Svingen, P.A., Peters, C., Kaufmann, S.H. and Gores, G.J., 2000, Cathepsin B contributes to TNF-a-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J. Clin. Invest. 106 1127-1137... 

T. Patel and G. J. Gores, Inhibition of bile-salt-induced hepatocyte apoptosis by the anti-oxidant lazaroid U83836E, Toxicol. Appl. Pharmacol, mi, 142(1), 116. 

T. Sodeman, S. F. Bronk, P. J. Roberts, H. Miyoshi and G. J. Gores, Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas, Am. J. Physiol. Gastrointest. Liver Physiol, 2000, 278(6), G992. 

B. Yerushalmi, R. Dahl, M. W. Devereaux, E. Gumpricht and R. J. Sokol, Bile-acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition. Hepatology, 2001, 33(3), 616. 

James, N.H., Soames, A.R. Roberts, R.A. (1998) Suppression of hepatocyte apoptosis and induction of DNA synthesis by the rat and mouse hepatocarcinogen diethylhexyl phthalate (DEHP) and the mouse hepatocarcinogen 1,4-dichlorobenzene (DCB). Arch Toxicol., 12, 784-790... 

Further study demonstrated that THS significantly inhibited hepatic DNA fragmentation, the emergence of apoptotic bodies and chromatin condensation in D-GalN/LPS-induced liver injury in mice. The extent of the inhibitory effect of THS on hepatocyte apoptosis at 5 hr paralleled that on serum ALT elevation at 8 hr [87]. As mentioned above, in this model, a large number of hepatocytes undergoing apoptotic cell death can... 

Two forms of cell death are described within hepatocytes, apoptosis and necrosis. As with other organs, apoptosis is often called programmed cell death and is a normal physiologic process. Individual cells are affected (Dahm and Jones, 1996), cell death is not associated with... 

Mak, K.M., Wen K., Ren, C., Lieber, C.S. Dilinoleoylphosphati-dylcholine reproduces the antiapoptotic actions of polyenylphosphatidylcholine against ethanol-induced hepatocyte apoptosis. Alcoh. Clin. Exp. Res. 2003 27 997-1005... 

Leist M, Gantner F, Bohlinger I, Tiegs G, Germann PG, Wendel A. 1995. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am. J. Pathol. 146 1220-34... 

Natori S, Rust C, Stadheim LM, Srinivasan A, Burgart LJ, Gores GJ. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. I Hepatol 2001 34 248-53. 

Gill, J. H., James, N. H., Roberts, R. A., and Dive, C. (1998). The non-genotoxic hepatocardnogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFbetal, DNA damage and Fas. Carcinogenesis 19, 299-304. 

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