Mouse lymphoma mutagenesis

Hozier, J., Sawyer, J., Moore, M., Howard, B., and Clive, D., Cytogenetic analysis of the L5178Y/TK TK mouse lymphoma mutagenesis assay system, Mutat. Res., 84,169,1981. [Pg.310]

Myhr, B.C., Bowers, L.R. Caspaiy, W.J. (1986) Results from the testing of coded chemicals in the L5178Y TK+ mouse lymphoma mutagenesis assay. Environ, mol. Mutagen., 7 (Suppl. 3), 58... [Pg.377]

TBHP did not produce a genotoxic response in the cell transformation assay, but did produce a mutagenic response in the Ames Salmonella) and mouse lymphoma mutagenesis assays. TBHP was tested for the induction of sex-linked recessive lethal mutations in Drosophila melanogaster, and was positive at a dose of 2000 ppm when administered to males by feeding. [Pg.1365]

API. 1987. The L5178Y Tk +/- mouse lymphoma mutagenesis assay with API 220 °-208°F distillate fraction of unleaded gasoline. Contract PS-61. Washington, DC American Petroleum Institute. Document no. FYI-AX-1187- 0536. [Pg.137]

TK mouse lymphoma mutagenesis assay system. Hutat. Res. [Pg.522]

Clive, D. (1987). Historical overview of the mouse lymphoma TK+/, mutagenicity assay. In Mammalian Cell Mutagenesis, (Moore, M.M., Demarini, D.M., De Serres, F.J. and Tindall, K.R., Eds.). Banbury Report 28. Cold Spring Harbor Laboratory, NY, pp. 25-36. [Pg.228]

McGregor DB, Brown AG, Howgate S, et al. 1991. Responses of the L5178Y mouse lymphoma cell forward mutation assay V 27 Coded chemicals. Environmental and Molecular Mutagenesis 17 196-219. [Pg.183]

Mutagenesis Entacapone was mutagenic and clastogenic in the in vitro mouse lymphoma/thymidine kinase assay in the presence and absence of metabolic activation, and was clastogenic in cultured human lymphocytes in the presence of metabolic activation. [Pg.1305]

Amacher, D.E. Paillet, S.C., and Turner, G.N. (1979b). Utility of the mouse lymphoma L5178Y/TK assay for the detection of chemical mutagens, in Banbury Report 2, Mammalian Cell Mutagenesis The Maturation of Tkst Systems, HsiE, A.W., O Neill, J.R, and McElheny, V.K, Eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York). [Pg.131]

Cole, J. and Arlett, C.E (1978). Methyl methanesulphonate mutagenesis in L5178Y mouse lymphoma cells, Mutat Res. 50, 111. [Pg.136]

Myhr BC, Caspary WJ. 1991. Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells Results for 31 coded compounds in the National Toxicology Program. Environ Mol Mutagen 18 51-83. [Pg.443]

Wangenheim, J. Bolcsfoldi, G. (1988) Mouse lymphoma L5178 Y thymidine kinase locus assay of 50 compounds. Mutagenesis, 3, 193-205... [Pg.335]

Mitchell. A.D., Rudd, C.J. Caspary, W.J. (1988) Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay intralaboratory results for sixty-three coded chemicals tested at SRI International. Environ, mol. Mutag., 12 (Suppl. 13). 37-101... [Pg.570]

Moore, M.M., Harrington-Brock, K., Doerr, C.L. Dearfield, K.L. (1989) Differential mutant quantitation at the mouse lymphoma tk and CHO hgprt loci. Mutagenesis, 4, 394-40.3... [Pg.1076]

Sofuni, T., Honma. M.. Hayashi, M., Shimada, H., Tanaka, N., Wakuri, S., Awogi, T., Yamamoto, K.I., Nishi, Y. Nakadate, M. (1996) Detection of in vitro clastogens and spindle poisons by the mouse lymphoma assay using the microwell method interim report of an international collaborative study. Mutagenesis, 11, 349-355... [Pg.1338]

Genotoxicity in mouse lymphoma cells of chemicals capable of Michael addition. Mutagenesis, 6, 519-525... [Pg.1454]

Chlorobenzene is one of 47 chemicals to be tested by NTP for heritable genetic effects in Drosophila and for mutagenesis in the mouse lymphoma cell mutagenesis assay. [Pg.50]

Dieldrin has been undergoing in vitro mutagenesis/genetic toxicity testing (CH0 cells) to have been completed in 1985. Testing on endrin for mammalian mutagenesis/genetic toxicity (mouse lymphoma cells) was to have started in 1985 (ref. 89, pp. 37 and 49). [Pg.330]

Isis Compound Number Salmonella E. coli Cytogenetics (Chromosomal Aberation) Mouse Lymphoma Mammalian Mutagenesis CHO/HGPRT Mammalian Mutagenesis Rat Hepatocyte UDS Mouse Micronucleus... [Pg.550]

Lymphoma Mutagenesis in the L5178Y TK+/- Mouse with Colony Size Evaluation in the Presence and Absences of... [Pg.852]

Lymphoma Mutagenesis in the L5178YTK +/- Mouse with Colony Size Evaluation in the Presence and Absence of Induced Rat Liver S-9 with a Confirmatory Study ICH S2A Specific Aspects of Regulatory Genotoxicity Tests for Pharmaceuticals and ICH S2B Genotoxicity A Standard Battery of Genotoxicity Testing of Pharmaceuticals and 2-A 4-8 15,000-25,000... [Pg.909]

Molinate was positive in the mouse lymphoma (with metabolic activation) and mouse micronucleus assays. It was negative in other mutagenesis tests including Ames assays. [Pg.1728]

Moore MM, Honma M, Clements J, et al. (2002) Mouse lymphoma thymidine kinase gene mutation assay followup International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000. Environmental and Molecular Mutagenesis 40(4) 292-299. [Pg.1746]

In regulatory decisions, the primary standard in vitro methods are the genotoxicity assays, including the Ames test and the mouse lymphoma cell mutagenesis assay. Animal and human respiratory tract cells or tissues in culture are frequently used for... [Pg.2253]

Clive D, Glover P, Applegate M, Hozier J (1990) Molecular aspects of chemical mutagenesis in L5178Y/tk +/- mouse lymphoma cells. Mutagenesis 5 191-197... [Pg.328]

Caspary WJ, Daston DS, Myhr BC, et al. 1988. Evaluation ofthe L5178Y mouse lymphoma cell mutagenesis assay interlaboratory reproducibility and assessment. Environ Mol Mutagen 12(Suppl 13) 195- 229. [Pg.193]

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