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Mouse lymphoma assay

Brusick and Matheson (1976) reported that 1,1-dimethylhydrazine failed to increase reversions in Salmonella typhimurium or Saccharomyces cerevisiae gene mutation assays with or without metabolic activation. A concentration-related response was observed in the mouse lymphoma assay (with activation). Dominant lethal tests were negative. [Pg.188]

In vitro mammalian cell test (chromosome aberration test or mouse lymphoma assay)... [Pg.4]

The L5178Y mouse lymphoma assay (MLA) for mutants at the TK locus. [Pg.193]

Clive, D., Caspary, W., Kirkby, RE., Krehl, R., Moore, M., Mayo, J. and Oberly, T.J. (1987). Guide for performing the mouse lymphoma assay for mammalian cell mutagenicity. Mutation Res. 189 145-146. [Pg.228]

Cyclopentane was not mutagenic in the Ames bacterial assay it was also negative in vitro in the mouse lymphoma assay and in the micronucleus test. ... [Pg.200]

Trimethyl phosphite was genotoxic in mouse lymphoma assays but was not mutagenic in various bacterial assays. ... [Pg.714]

Tablets - The in vitro mouse lymphoma assay demonstrated mutagenic activity. [Pg.1780]

IVC, in vitro chromosome aberration MLA, mouse lymphoma assay MN, micronucleus test. Upper dark circles, sensitivity lower light circles, specificity. [Pg.244]

The mouse lymphoma assay is in fact just one of several mammalian cell assays designed to determine increases in mutation rate. It focuses on the thymidine kinase (tk) assay in murine lymphoma cells (L5178Y), though tk data have also been produced from the human lymphoblastoid cell line TK6, and at the hgprt (hypox-anthine-guanine phosphoribosyl-transferase) locus in Chinese Hamster ovary or lung (V79) cells and mouse lymphoma cells. Since Ames mutation data and often... [Pg.254]

Ethylbenzene was non-mutagenic in bacteria, yeast and insects. In mammalian cells, it was inactive in inducing sister chromatid exchanges in Chinese hamster embryo cells but very weakly positive in cultured human l5miphocytes. It did not induce micronuclei in vivo, although it was positive in Syrian hamster embryo cells in vitro. It also caused cell transformation in these cells. Ethylbenzene induced mutations in the mouse lymphoma assay, but only at the highest non-lethal concentration tested. [Pg.257]

T. (1996) Re-evaluation of chromosomal aberration induction on nine mouse lymphoma assay unique positive NTP carcinogens. Mutat. Res., 369, 243-252... [Pg.1140]

M., Jr, Morita, T., Watanabe, K., Hara, M., Odawara, K., Tanaka, N., Hayashi, M. Sofuni, T. (1996) Re-evaluation of chromosomal aberration induction on nine mouse lymphoma assay unique positive NTP carcinogens. Mutat. Res., 369, 243-252... [Pg.1264]

Sofuni, T., Honma. M.. Hayashi, M., Shimada, H., Tanaka, N., Wakuri, S., Awogi, T., Yamamoto, K.I., Nishi, Y. Nakadate, M. (1996) Detection of in vitro clastogens and spindle poisons by the mouse lymphoma assay using the microwell method interim report of an international collaborative study. Mutagenesis, 11, 349-355... [Pg.1338]

Several bacterial and mammalian short-term tests for genetic toxicity as well as their biochemical and genetic rationale are described in Chapter 21 on toxicity testing. They include the salmonella assay, the Chinese hamster ovary cell/hypoxanthine-guanine phosphoribosyl transferase assay, the mouse lymphoma assay, the mammalian transformation assay, sister chromatid exchange, and the chromosome aberration assay. [Pg.250]

Barber ED, Cifone M, Rundell J, et al. 2000. Results of the L5178Y mouse lymphoma assay and the balb/3T3 cell in vitro transformation assay for eight phthalate esters. J Appl Toxicol 20 69-80. [Pg.248]

Sofuni T, Wilcox P, Shimada H, Clements J, Honma M, Clive D, Green M, Thybaud V, San R-H, Elliott B-M, Muller L (1997) Mouse lymphoma workshop Victoria, British Columbia, Canada, March 27, 1996. Protocol issues regarding the use of the microwell method of the mouse lymphoma assay. Environ Mol Mutagen 29 434-438... [Pg.833]

See also Federal Insecticide, Fungicide, and Rodenticide Act, US Food and Drug Administration, US Genetic Toxicology Good Laboratory Practices (GLP) International Conference on Harmonisation Micronucleus Assay Mitomycin C Mouse Lymphoma Assay Redbook Toxicity Testing, Mutagenicity. [Pg.91]

Coal tar is mutagenic in the Salmonella typhimurium assay and the mouse lymphoma assay in the presence of an exogenous mammalian metabolic system. [Pg.630]

See also Ames Test Carcinogenesis Chromosome Aberrations Dominant Lethai Tests In HfroTest In Vivo Test Moiecuiar Toxicoiogy-Recombinant DNA Tech-noiogy Mouse Lymphoma Assay Sister Chromatid Exchanges Toxicity Testing, Aiternatives. [Pg.1344]

MEK was not mutagenic in Ames Salmonella) and Escherichia coli tests, but induced aneuploidy in Saccharomyces cerevisiae. MEK was not found to be genotoxic in the mouse lymphoma assay, in Chinese hamster ovary cell, unscheduled DNA synthesis assay, and micronucleus assays. [Pg.1662]

Mouse Lymphoma Assay, Pages 160-162, Robin C. Guy SummaryPlus Full Text + Links PDF (63 K)... [Pg.2374]

See also Ames Test Analytical Toxicology Aneuploidy Carcinogen-DNA Adduct Formation and DNA Repair Chromosome Aberrations Developmental Toxicology Dominant Lethal Tests Host-Mediated Assay Molecular Toxicology - Recombinant DNA Technology Mouse Lymphoma Assay Toxicity Testing, Mutagenicity. [Pg.2411]

See other pages where Mouse lymphoma assay is mentioned: [Pg.132]    [Pg.60]    [Pg.647]    [Pg.210]    [Pg.256]    [Pg.647]    [Pg.1141]    [Pg.1304]    [Pg.249]    [Pg.159]    [Pg.832]    [Pg.833]    [Pg.1414]    [Pg.137]    [Pg.355]    [Pg.904]    [Pg.1159]    [Pg.1201]    [Pg.1242]    [Pg.1744]    [Pg.1744]    [Pg.1745]    [Pg.2282]    [Pg.2598]   
See also in sourсe #XX -- [ Pg.254 ]

See also in sourсe #XX -- [ Pg.311 , Pg.314 ]



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