Sex linked recessive lethal

TK or HPRT forward mutation assays in cultured mammalian ceils Drosophila sex-linked recessive lethal assay... 

Tripathy NK, Dey L, Majhi B, et al. 1987. Genotoxicity of metacid established through the somatic and germ line mosaic assays and the sex-linked recessive lethal test in drosophila. Arch Toxicol 61 53-57. 

Insect systems Drosophila melanogaster (sex-linked recessive lethal test) Recessive lethal mutation + Velazquez et al. 1984... 

Drosophib melanogaster Sex-linked recessive lethal - EPA 1981a Sandhu et al. 1985 ... 

Sex-linked recessive lethal mutations were not produced in Drosophila fed ethanol solution containing 50 ppm 1,2-diphenylhydrazine for 3 days (Yoon et al. 1985). No oral genotoxicity studies of 1,2-diphenylhydrazine in mammals were located. 

Sex-linked recessive lethal test in Drosophila melanogaster (August 1998)... 

B.20 Sex-Linked Recessive Lethal Test in Drosophila melanogaster (1988)... 

The sex-linked recessive lethal (SLRL) test in Drosophila melanogaster OECD TG All US-EPA OPPTS 870.5275 EU Annex V B.20... 

IGE was mutagenic in bacterial assays with and without metabolic activation and in the Drosophila sex-linked recessive lethal (SERE)... 

Eukaryotic organisms (in vivo) Drosophila nelanogastfir 1989d Sex-linked recessive lethal No data - Hazleton Labs... 

Hazleton Labs. 1989d. Mutagenicity test on ortho-cresol (lot number RC645A) Drosophila Melanogaster sex-linked recessive lethal test. HLA study no. 10004-0-461. Unpublished data submitted to Chemical Manufacturers Association, Washington, DC. 

Vogel, E., Blijleven, W.G.H., Kortselius, M.J.H. and Zijlstra, J.A. (1981) Mutagenic activity of 17 coded compounds in the sex-linked recessive lethal test in Drosophila melanogaster, in Progress in Mutation Research, Volume 1 Evaluation of Short-Term Tests Carcinogens (eds F.J. de Serres and J. Ashby), Elsevier, Amsterdam. 

In a test for sex-linked recessive lethal mutations in Drosophila, Wild et al. 8 found no evidence of mutagenicity of CS. More than 9,000 chromosomes were tested, and the frequencies of mutations in the treated groups did not differ from those in the concurrent negative controls or the historical negative controls. The available information on the toxicity of CS under the treatment conditions is minimal. The actual dosages received by the flies are also uncertain, particularly because CS breaks down rapidly in water. Nevertheless, the available data give no indication of mutagenicity of CS in Drosophila. 

Like many other Irritants, PS has not been tested thoroughly for mutagenicity. However, in one early study, Auerbach tested its capacity to Induce sex-linked recessive lethal mutations In the fruit fly, Drosophila melanogaster. In all broods of flies derived from PS-treated males, the mutation frequencies were consistent with those of untreated laboratory stocks. A total of 4,454 chromosomes were tested, and the mutation frequency was 0.2%. In contrast, flies treated with mustard gas had a frequency of 5.2%. 

A small increase in somatic mutation frequency was reported in the eye-colour spot test with Drosophila melanogaster exposed to di(2-ethylhexyl) phthalate in the feed but no effect was observed in two independent wing-spot tests. In a single study, mitotic recombination was not induced by di(2-ethylhexyl) phthalate neither was sex-linked recessive lethal mutation induced in two studies in D. melanogaster treated with di(2-ethylhexyl) phthalate in the feed or by injection. When administered to D. melanogaster, di(2-ethylhexyl) phthalate and A-nitrosodiethylamine induced DNA double-strand breakage and DNA repair, although neither compound was active when administered alone. 

Di(2-ethylhexyl) adipate did not induce gene mutations, sister chromatid exchanges, chromosomal aberrations or micronuclei in rodent cells in vitro. It did not induce sex-linked recessive lethal mutations in Drosophila when administered either by diet or injection. Di(2-ethylhexyl) adipate was not mutagenic to either Photo-... 

Drosophila melanogaster, sex-linked recessive lethal mutations - 1267 in feed Wild el a/. (1983)... 

Sex-linked recessive lethal mutations were not induced in Drosophila melano-gaster. Coumarin did not induce either micronuclei in mice or unscheduled DNA... 

Bacillus subtilis H17 rec MA5 recT, DNA damage assay Saccharomyces cerevisiae JDl, gene conversion Drosophila melanogaster, sex-linked recessive lethal mutation Unscheduled DNA synthesis, primary rat hepatocytes in vitro Sister chromatid exchange, Chinese hamster ovary CHO cells in vitro... 

Drosophila melanogaster, sex-linked recessive lethal -H 500 ppm in feed Yoon etal. (1985) National... 

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