Thymidine kinase locus

Mouse lymphoma L5178Y thymidine kinase locus... 

Myhr B, Bowers L, Caspary WJ. 1985. Assays for the induction of gene mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells in culture. In Ashby J, de Serres FJ, et al., eds. Progress in mutation research. Vol. 5. Evaluation of short-term tests for carcinogens. Amsterdam, The Netherlands Elsevier Science Publishers, 555-568. 

Amacher, D.E., S C Pail lei. G.N.Tumer, V.A.Ray, and D.S.Salsburg. 1980. Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells. II. Test validation and interpretation. Mutat. Res. 72 447-474. 

The mouse lymphoma forward mutation test at the thymidine kinase locus (detects mutations to a nonfunctional thymidine kinase in a line of culture mouse lymphoma cells). 

Cifone, M.A., Myhr, B., Eiche, A. and Bolisfodi, G. (1987). Effect of pH shifts on the mutant frequency at the thymidine kinase locus in mouse lymphoma L5178Y TK+/— cells. Mutation Res. 189 39-46. 

Clive, D., Flamm, W.G. and Patterson, J.B. (1972). A mutational assay system using the thymidine kinase locus in mouse lymphoma cells. Mutation Res. 16 77-87. 

Oberly, T.J., Bewsey, B.J. Probst, G.S. (1985) Tests for the induction of forward mutation at the thymidine kinase locus of L5178Y mouse lymphoma cells in culture. Prog. Mutat. Res., 5, 569-582... 

Henry B, Grant SG, Klopman G, et al. 1998. Induction of forward mutations at the thymidine kinase locus of mouse lyphoma cells evidence for electrophilic and non-electrophilic mechanisms. Mutat Res 397(2) 313-335. 

Myhr BC, Caspary WJ. 1991. Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells Results for 31 coded compounds in the National Toxicology Program. Environ Mol Mutagen 18 51-83. 

Wangenheim, J. Bolcsfoldi, G. (1988) Mouse lymphoma L5178 Y thymidine kinase locus assay of 50 compounds. Mutagenesis, 3, 193-205... 

Jotz, M.M. Mitchell, A.D. (1981) Effects of 20 coded chemicals on the forward mutation frequency at the thymidine kinase locus in L5178Y mouse lymphoma cells. In de Serres, F.J. Ashby, J., eds. Evaluation of Short-Term Tests for Carcinogens. Report of the International Collaborative Progrcm (Progress in Mutation Research, Vol. 1), Amsterdam, Elsevier, pp. 580-593... 

What is the potential of a test article with and without metabolic activation to induce forward mutations at the thymidine kinase locus of L5178Y TK+/-mouse lymphoma cells ... 

Applegate ML, Moore MM, Broder CB, Burrell A, Juhn G et al (1990) Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells. Proc Natl Acad Sci U S A 87 51-55... 

Liber HL, Thilly WG (1982) Mutation assay at the thymidine kinase locus in diploid human lymphoblasts. Mutat Res 94 467-485... 

Amacher, O.E., Paillet, S. and Ray, V.A. (1979). Point mutations at the thymidine kinase locus in LS178Y mouse lymphoma cells, I. Application to genetic toxicology testing. Mutat. Res. 64, 391-406. 

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