Mutation data

The mutation data on the conserved sequences of the putative ATP binding site is summarized in Fig. 8 [103]. 

Jones, D. T., Taylor, W. R., and Thornton, J. M. (1992). The rapid generation of mutation data matrices from protein sequences. Comput. Appl. Biosci. 8, 275—282. 

The mouse lymphoma assay is in fact just one of several mammalian cell assays designed to determine increases in mutation rate. It focuses on the thymidine kinase (tk) assay in murine lymphoma cells (L5178Y), though tk data have also been produced from the human lymphoblastoid cell line TK6, and at the hgprt (hypox-anthine-guanine phosphoribosyl-transferase) locus in Chinese Hamster ovary or lung (V79) cells and mouse lymphoma cells. Since Ames mutation data and often... 

Noteworthy in this perspective is the recent work done at Pfizer and Biofocus (see Section 5.5), where, based on analysis of sequence data, mutation data, and physicochemical properties of the ligands, approaches were outlined for discovering sequence patterns characteristic of specific ligand classes. Pfizer applied the approach successfully to the construction of a sequence motif characteristic of monoamine GPCRs [74],... 

George, D.G., Barker, W.C., Hunt, L.T. (1990) Mutation Data Matrix and Its Uses, Methods Enzymol. 183, 333-351. 

Other experimental reproductive effects. A skin and severe eye irritant. A narcotic. Human mutation data reported. A common air contaminant. Highly flammable liquid. NCxmres of 30-60% of the vapor in air ignite above 100°. It can react violently with acid anhydrides, alcohols, ketones, phenols, NH3, HCN, H2S, halogens, P, isocyanates, strong alkalies, and amines. Reactions with cobalt chloride, mercury(II) chlorate, or mercury(II) perchlorate form violendy in the presence of traces of metals or acids. Reaction with oxygen may lead to detonation. When heated to decomposition it emits acrid smoke and fumes. 

Flammable Liquid SAFETY PROFILE Poison via intraperitoneal route. Mutation data reported. A dangerous fire hazard with a flash point at room temperamre. When heated to decomposition it emits toxic fumes of NOx. See also ALDEHYDES. 

SAFETY PROFILE A human poison by an unspecified route. Poison by ingestion and intravenous routes. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion hallucinations and distorted perceptions, sleepiness, constipation, cyanosis, respiratory stimulation, kidney damage, methemoglobinemia-carboxyhemoglobinemia, and decreased body temperature. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Combustible when exposed to heat or flame. See also ANILINE. 

DOT CLASSIFICATION 8 Label Corrosive SAFETY PROFILE A human poison by an unspecified route. Moderately toxic by various routes. A severe eye and skin irritant. Can cause burns, lachrymation, and conjunctivitis. Human systemic effects by ingestion changes in the esophagus, ulceration, or bleeding from the small and large intestines. Human systemic irritant effects and mucous membrane irritant. Experimental reproductive effects. Mutation data reported. A common air contaminant. 

SAFETY PROFILE Moderately toxic by ingestion. Mutation data reported. An allergen. Implicated in aplastic anemia. A 10 gram dose may be fatal to an adult. Skin contact, inhalation, or ingestion can cause asthma, sneezing, irritation of eyes and nose, hives, and eczema. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and fumes. 

OSHA PEL TWA 500 g(As)/m3 ACGIH TLV BEL 35 n (As)/L inorganic arsenic and methylated metabolites in urine SAFETY PROFILE Poison by ingestion and intravenous routes. Human systemic effects by ingestion respiratory system, endocrine system, dermatitis, and fever. Human systemic effects by intravaginal route hallucinations, distorted perceptions, convulsions, nausea or vomiting, decreased urine volume, and fever. Mutation data reported. See also ARSENIC COMPOUNDS. When heated to... 

SAFETY PROFILE Poison by ingestion and intraperitoneal routes. Moderately toxic by inhalation. A skin and severe eye irritant. Experimental reproductive effects. Mutation data reported. Flammable liquid when exposed to heat or flame. Incompatible with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. 

---