Salmonella assay

Houk VS, Schaikowsky S, Claxton LD. 1989. Development and validation of the spiral Salmonella assay An automated approach to bacterial mutagenicity testing. Mutat Res 223 49-64. [Pg.237]

Prival, M.J., Bell, S.J., Mitchell, VD., Peiperi, M.D. and Vaughn, VL. (1984). Mutagenicity of benzidine and benzidine-congener dyes and selected monoazo dyes in a modified Salmonella assay. Mutation Res. 136 33-47. [Pg.234]

G.A. Umbuzeiro, H. Freeman, S.H. Warren, F. Kummrow and L.D. Claxton, Mutagenicity evaluation of the commercial product Cl Disperse Blue 291 using different protocols of the Salmonella assay. Food Chem. Toxicol. 43 (2005) 49-56. [Pg.563]

G.A. Umbuzeiro, D.A. Roubicek, C.M. Rech, M.I.Z. Sato and L.D. Claxton, Investigating the sources of the mutagenic activity found in a river using the Salmonella assay and different water extraction procedures. Chemosphere, 54 (2004) 1589-1597. [Pg.563]

Hughes TJ, Simmons DM, Monteith LG, et al. 1987. Vaporization technique to measure mutagenic activity of volatile organic chemicals in the Ames/ Salmonella assay. Environ Mutagen 9 421-441. [Pg.121]

Arochlor 54 was not mutagenic in Salmonella assays it was not genotoxic in rodent assays in vivo. ... [Pg.157]

Chloro-l-nitropropane was mutagenic in Salmonella assays both with and without activation. [Pg.164]

Studies in several test systems have shown DCB to be genotoxic in vitro and in vivo and suggest that this effect most likely mediates the carcinogenicity of the chemical. In vitro, DCB has induced sister chromatid exchanges, unscheduled DNA synthesis, and positive responses in bacterial Salmonella assays in vivo DCB induced micronuclei in polychromatic erythrocytes in male mice and fetuses. ... [Pg.224]

Dichloroethane did not act as a tumor initiator or as a complete carcinogen in a rat liver foci assay. Positive results were seen for tumor promotion in the presence of an initiator. It has produced both positive and negative results in Salmonella assays. [Pg.227]

DMMP was not mutagenic in Salmonella assays. An ACGIH threshold limit value (TLV) has not been established for dimethyl methylphosphonate. [Pg.271]

Ethyl bromide was mutagenic in Salmonella assays with and without microsomal activation when tested in an enclosed system it also induced sister chromatid exchange in Chinese hamster ovary cells. ... [Pg.313]

HDI was not mutagenic against a variety of Salmonella assays with or without metabolic activation. ... [Pg.378]

Methyl acrylate was not found to be mutagenic in the Salmonella assay, but it increased chromosomal aberrations in vitro and tested positive in the micronucleus assay in mice. ... [Pg.451]

Nitropropane is mutagenic in V79 cells and can induce unscheduled DNA synthesis in rat hepatocytes, but it was not mutagenic in Salmonella assays, nor did it produce sister chromatid exchanges or chromosomal aberrations in vitro. [Pg.530]

Nitropropane is genotoxic in a variety of assays including the kmes Salmonella assay, in vitro sister chromatid exchange, and chromosome aberrations and unscheduled DNA synthesis assay. ... [Pg.532]

Picric acid was mutagenic in the Ames Salmonella assay in the presence of metabolic activation. ... [Pg.588]

Negative results were reported in various mutagenic assays including the Ames Salmonella assay (with or without microsomal activation), sister chromatid exchange assay in mouse lymphoma cells, mouse bone marrow cyto-genic analysis, and mouse dominant lethal assay ... [Pg.607]

Stark and co-workers (1985) reported that irradiation of a 0.1 mM solution of 1-nitropyrene in 2-propanol with light from 320 to 418 nm changes its absorption spectrum and concurrently results in almost total loss of its direct ( —S9) or activatable ( + S9) mutagen activity in the Ames Salmonella assay. [Pg.519]

Hughes, T. J., D. M. Simmons, L. G. Monteith, and L. D. Claxton, Vaporization Technique to Measure Mutagenic Activity of Volatile Organic Chemicals in the Ames/Salmonella Assay, Environ. Mutagen., 9, 421-441 (1987). [Pg.535]

Lofroth, G, Nilsson, L. Andersen, J.R. (1986) Stracture-activity relationship of nitroalkane-induced mutagenicity in the Ames Salmonella assay. Genetic toxicology of environmental chemicals, Part B Genetic effects and applied mutagenesis. Prog. din. biol. Res., 209B, 149-155... [Pg.500]

Galli, A. Schiestl, R.H. (1996) Effects of Salmonella assay negative and positive carcinogens on intrachromosomal recombination in Gi-arrested yeast cells. Mutat. Res., 370, 209-221... [Pg.426]

Nestmann, E.R., Otson, R., Kowbel, D.J., Bothwell, PD. Harrington, T.R. (1984) Mutagenicity in a modified Salmonella assay of fabric-protecting products containing 1,1,1-trichloroethane. Environ. Mutag., 6, 71-80... [Pg.900]

Morita, T., Iwamoto, Y., Shimizu, T., Masuzawa, T. Yanagihara, Y. (1989) Mutagenicity tests with a permeable mutant of yeast on carcinogens showing false-negative in Salmonella assay. Chem. pharm. Bull., 31, 407-409... [Pg.1220]

Protocols for preparing six environmental sample types prior to the Ames Salmonella assay were proposed at a recent panel discussion sponsored by the U.S. Environmental Protection Agency (USEPA) and the U.S. Army. Air particles, soil-sediment, and solid waste are extracted with dichloromethane, concentrated, and solvent exchanged into dimethyl sulfoxide (DMSO). Organics in water and waste water are absorbed onto XAD columns, then eluted with hexane-acetone, solvent reduced, and exchanged into DM SO. Nonaqueous liquids are assayed directly and as concentrates before they are solvent exchanged to DMSO. If bacterial toxicity or lack of dose response is observed in the Ames assay of extracts, the extracts are fractionated prior to solvent exchange. These are interim methods and have not been subjected to policy review of the USEPA or the U.S. Army. [Pg.25]

A number of issues were addressed in the general sessions that were common to all six of the proposed protocols. These included definitions of each of the sample media, limitations of the protocols, guidelines for the fractionation of samples found to be toxic in the Salmonella assay, and analytical quality control considerations. [Pg.26]

Several bacterial and mammalian short-term tests for genetic toxicity as well as their biochemical and genetic rationale are described in Chapter 21 on toxicity testing. They include the salmonella assay, the Chinese hamster ovary cell/hypoxanthine-guanine phosphoribosyl transferase assay, the mouse lymphoma assay, the mammalian transformation assay, sister chromatid exchange, and the chromosome aberration assay. [Pg.250]

Santana-Rios, G., Omer, G.A., Amantana, A., Provost C., Wu, S.Y., and Dashwood, R.H. Potent antimutagenic activity of white tea in comparison with green tea in the salmonella assay. Mutat. Res., 495, 61-74, 2001. [Pg.667]

D.B. Walsh, L.D. Claxton, Computer-assisted structure-activity relationships of nitrogenous cyclic compounds tested in Salmonella assays for mutagenicity. Mutat. Res. 182, 55-64 (1987)... [Pg.239]

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