Host-mediated assay

Simmon VF, Rosenkranz HS, Zeiger E. et al. 1979. Mutagenic activity of chemical carcinogens and related compounds in the intraperitoneal host- mediated assay. J Nat Cancer Inst 62 911-918. [Pg.575]

Monomethylhydrazine-induced mutagenesis was not observed in Ames Salmonella/ microsome with activation (Matheson et al. 1978). In vivo tests in mice (dominant lethal, revertants in host-mediated assay), and dogs (micronuclei) were negative (reviewed in Trochimowicz 1994). However, in vitro chromosomal damage in human and rat tissue has been demonstrated, although in vivo liver DNA damage (as determined by DNA alkaline elution) was equivocal (reviewed in Trochimowicz 1994). [Pg.147]

Quarles, J.M., J.O. Norman, and L.F. Kubena. 1980. Absence of transformation by diflubenzuron in a host-mediated transplacental carcinogen assay. Bull. Environ, Contam. Toxicol. 25 252-256. [Pg.1021]

Serratia marcescens (a21)/host mediated assay Bacillus subtilis/spot test E. coli/spot test B. subtilis/spot test E. coli/spot test... [Pg.65]

Buselmaier W, Roehrborn G, Propping P. 1972. [Mutagenicity investigations with pesticides in host-mediated assay and dominant lethal test in mice], Biol ZbI 91 311-325. [Pg.114]

Host-mediated assays Salmonella ty TA1535 (mouse host-mediated assay) Reverse mutation San Agustin and Lim-Sylianco 1978... [Pg.160]

Apostolidis S, Chandra T, Demirhan I, Cinatl J, Doerr HW, Chandra A (2002) Evaluation of carcinogenic potential of two nitro-musk derivatives, musk xylene and musk tibetene in a host-mediated in vivo/in vitro assay system. Anticancer Res 22 2657-2662... [Pg.299]

The detection of chemical mutagens using the L5178Y/Asn-murine leukemia in vitro and in a host-mediated assay. Cancer Res. 34 3073-3082, 1974. [Pg.129]

Host-mediated assay, E. coli K-12/343/113 forward mutation (VAL ) in male Swiss albino mouse liver and spleen in vivo Host-mediated assay, E. coli K-12 uvrBIrecA and (differential... [Pg.426]

HMM, Host-mediated assay, reverse mutation in Salmonella + 444 im Simmon etal. (1979)... [Pg.188]

In the mouse host-mediated assay, diepoxybutane induced mutation in. S typhimurium TA1530 but did not induce mitotic recombination in Saccharomyces cerevisiae D3. [Pg.192]

Hellmer,L. Bolcsfoldi, G. (1992)An evaluation oftheA. coli K-12 uvrBlrecA DNA repair host-mediated assay. I. In vitro sensitivity of the bacteria to 61 compounds. Mutat. Res., I ll, 145-160... [Pg.333]

Catechol did not induce gene mutations in Salmonella typhimurium or DNA repair in a mouse host-mediated assay in Escherichia coli. [Pg.442]

HMM, Host-mediated assay, Escherichia coli K-12 uvr B/rec A DNA - 200 po X 1 Hellmer Bolcsfoldi... [Pg.444]

In a single study, epichlorohydrin bound to DNA of mice and rats treated in vivo. One study reported that sister chromatid exchanges were induced in the bone marrow of partially hepatectomized CBA/J mice treated with epichlorohydrin by a single intraperitoneal injection. Sister chromatid exchange frequencies in mice that did not receive partial hepatectomy before treatment with epichlorohydrin were comparable to the control frequencies. One of two studies reported that epichlorohydrin induced chromosomal aberrations in mouse bone marrow. Positive results were also reported for epichlorohydrin in the mouse host-mediated assay in one of three studies. In single studies, epichlorohydrin caused sperm head abnormalities in rats but not mice. It did not induce micronuclei or dominant lethal mutations in mice in vivo. [Pg.618]

CHL, Chromosomal aberrations, human lymphocytes in vitro HMM, Host-mediated assay in NMRI mice MST, Spot test, C57BL/6JHan x T mice MVA, Micronucleus test, amphibian Caudiverbera caudiverbera larvae in vivo (+) NT 90 75 sc X 1 50 ip X 1 1.5 ug/nil. Ziemsenefa/. (1987) Busehnaier et al. (1972) Fahrig etal. (1978) Venegas etal. (1993)... [Pg.802]

Buselmaier, W., Rohrbom, G. Propping, P. (1972) Mutagenicity investigations with pesticides in the host-mediated assay and with the dominant lethal test in the mouse. Biol. Zentralblatt, 91, 311-325 (in German)... [Pg.807]

There is conflicting evidence concerning the mutagenicity of 1,2-dimethylhydrazine to bacteria. In a single study, it induced recombination in Saccharomyces cerevisiae. In vitro, 1,2-dimcthylhydrazine formed DNA adducts in human bronchial cells, provoked unscheduled DNA synthesis in rat hepatocytes and induced gene mutation in mammalian cells. It gave positive results in rodents in microbial host-mediated assays. [Pg.975]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...