L5178Y mouse lymphoma assay

The L5178Y mouse lymphoma assay (MLA) for mutants at the TK locus. [Pg.193]

Barber ED, Cifone M, Rundell J, et al. 2000. Results of the L5178Y mouse lymphoma assay and the balb/3T3 cell in vitro transformation assay for eight phthalate esters. J Appl Toxicol 20 69-80. [Pg.248]

Oberly TJ, Piper CE, McDonald DS. 1982. Mutagenicity of metal salts in the L5178Y mouse lymphoma assay. J Toxicol Environ Health 9 367-376. [Pg.634]

Nocentini S (1987) Inhibition of DNA replication and repair by cadmium in mammalian cells. Protective interaction by zinc. Nucleic Acids Res 15 4211-4225 Oberly TJ, Piper CE, McDonald DS (1982) Mutagenicity of metal salts in the L5178Y mouse lymphoma assay. J Toxicol Environ Health 9 367-376 Ochi T, Ohsawa M (1983) Induction of 6-thioguanine-resistant mutants and singlestrand scission of DNA by cadmium chloride in cultured Chinese hamster cells. Mutat Res 111 69-78... [Pg.401]

Myhr B, Bowers L, Caspary WJ. 1985. Assays for the induction of gene mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells in culture. In Ashby J, de Serres FJ, et al., eds. Progress in mutation research. Vol. 5. Evaluation of short-term tests for carcinogens. Amsterdam, The Netherlands Elsevier Science Publishers, 555-568. [Pg.114]

McGregor, D.B., A.G.Brown, S.Howgate, D.McBride, C.Riach, and W.J.Caspary. 1991. Responses of the L5178Y mouse lymphoma cell forward mutation assay. V. 27 coded chemicals. Environ. Mol. Mutagen. 17 196-219. [Pg.68]

Matheson et al. (1978) reported the results of a battery of in vivo and in vitro assays to assess the genotoxicity of 1,1-dimethylhydrazine. Included were the Ames Salmonella microsome assay, a microbial suspension assay, mutation induction at the TK locus in L5178Y mouse lymphoma cells, stimulation of UDS in WI-38 cells, and a dominant lethal assay in mice. 1,1-Dimethylhydrazine was active in all of the tests except the dominant lethal assay. [Pg.189]

The mouse lymphoma assay is in fact just one of several mammalian cell assays designed to determine increases in mutation rate. It focuses on the thymidine kinase (tk) assay in murine lymphoma cells (L5178Y), though tk data have also been produced from the human lymphoblastoid cell line TK6, and at the hgprt (hypox-anthine-guanine phosphoribosyl-transferase) locus in Chinese Hamster ovary or lung (V79) cells and mouse lymphoma cells. Since Ames mutation data and often... [Pg.254]

Kilby, P.E., Pizzarello, R.F., Lawlor, T.E., Haworth, S.R. Hodgson, J.R. (1983) Evaluation of di-(2-ethylhexyl)phthalate and its major metabolites in the Ames test and L5178Y mouse lymphoma mutagenicity assay. Environ. Mutag., 5, 657-663... [Pg.135]

Myhr B, McGregor D, Bowers L, et al. 1990. L5178Y Mouse lymphoma cell mutation assay results with 41 compounds. Environ Mol Mutagen 16 138-167. [Pg.443]

McGregor, D., Brown, A.G., Cattanach, P., Edwards, I., McBride, D., Riach, C., Shepherd, W. Caspary, W.J. (1991) Responses of the L5178Y mouse lymphoma forward mutation assay V. Gases and vapors. Environ, mol. Mutag., 17, 122-129... [Pg.215]

Mitchell. A.D., Rudd, C.J. Caspary, W.J. (1988) Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay intralaboratory results for sixty-three coded chemicals tested at SRI International. Environ, mol. Mutag., 12 (Suppl. 13). 37-101... [Pg.570]

Caspary. W.J. (1991) Responses of the L5178Y mouse lymphoma forward mutation assay V. [Pg.1178]

Majeska JB and Holden HE (1994) Procedure for reduction of test chemical requirement in preliminary assays using the L5178Y + mouse lymphoma forward... [Pg.1746]

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