Carcinogenesis chromosomal aberrations

See also Ames Test Carcinogenesis Chromosome Aberrations Dominant Lethai Tests In HfroTest In Vivo Test Moiecuiar Toxicoiogy-Recombinant DNA Tech-noiogy Mouse Lymphoma Assay Sister Chromatid Exchanges Toxicity Testing, Aiternatives. 

See also Carcinogenesis Chromosome Aberrations Deveiopmentai Toxicoiogy Gastrointestinai System Met-ais Moiecuiar Toxicoiogy-Recombinant DNA Tech-noiogy Occupationai Toxicoiogy Poiiution, Air Indoor Respiratory Tract Risk Assessment, Human Heaith Skeietai System Skin. 

Connell, J.R. and Medcalf, A.S. (1982). The induction of SCE and chromosomal aberrations with relation to specific base methylation of DNA in Chinese hamster cells by N-methyl-n-nitrosourea and dimethyl sulphate. Carcinogenesis 3 385-390. 

Popp, J.A., Garvey, L.K., Hamm, T.E., Jr Swenberg, J.A. (1985) Lack of hepatic promotional activity by the peroxisomal proliferating hepatocarcinogen di(2-ethylhexyl)phthalate. Carcinogenesis, 6,141-144 Preston, M.R. Al-Omran, L.A. (1989) Phthalate ester speciation in estuarine water, suspended particulates and sediments. Environ. Pollut., 62, 183-193 Priston, R.A.J. Dean, B.J. (1985) Tests for the induction of chromosome aberrations, polyploidy and sister-chromatic exchanges in rat liver (RL4) cells. Prog. Mutat. Res., 5, 387-395... 

Irons, R.D., Oshimura, M. Barrett, J.C. (1987b) Chromosome aberrations in mouse bone marrow cells following in vivo exposure to 1,3-butadiene. Carcinogenesis, 8, 1711-1714... 

Sarto F, Cominato I, Bianchi V, et al. 1982. Increased incidence of chromosomal aberrations and sister chromatid exchanges in workers exposed to chromic acid (Cr03) in electroplating factories. Carcinogenesis 3(9) 1011-1016. 

A number of short-term tests can be used to determine the genotoxic potential of chemicals. These tests use both prokaryotic and eukaryotic cells and measure such end points as gene mutations, chromosomal aberrations, and interactions with critical macromolecules It is widely recognized chat no test can detect all genotoxic compounds, and multiple end points are required to provide a reliable assessment of genotoxiclty. Information from several tests can be combined to reveal two important toxic effects carcinogenesis and mutagenesis. 

In view of the apparent relationship between chromosomal damage, mutagenesis and carcinogenesis [8-10], analyses of induced chromosomal aberrations have become a useful tool to evaluate potential hazards of environmental or occupational mutagens and carcinogens. The underlying premise, inherent in somatic mutation theory of cancer, is that an elevated frequency of chromosomal aberrations would increase the likelihood of the rearrangements that contribute to neoplastic transformation [11-13]. 

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