Laxative effect

The magnesium- and sodium-containing antacids may have a laxative effect and produce diarrhea Ahiminum-and calcium-containing products tend to produce constipation. Some of the less common but more serious adverse reactions include ... 

Magnesium-containing products may produce a laxative effect and may cause diarrhea aluminum- or calcium-containing antacids may cause constipation magnesium-containing antacids are used to avoid bowel dysfunction. 

Aloe vera Aloe vera Inhibits infection and promotes healing of minor burns and wounds None significant if used as directed may cause burning sensation in wound Rare reports of delayed healing when used in the gel form on a wound. Taken internally, aloe gel may have laxative effect. 

Salatrim is a mixture of many triglycerides that have the characteristics mentioned above. Because it is partially absorbed, Salatrim does not have the problems associated with Olestra. It does not have any laxative effects nor does it prevent the absorption of fat-soluble vitamins and carotenoids. 

Food-grade or medicinal mineral oil, a mixture of aliphatic hydrocarbons that also may be found in mineral oil hydraulic fluids, is known to be absorbed only to a limited extent by the human gastrointestinal tract and has a laxative effect (Anonymous 1967 Brunton 1985), thus suggesting that mineral oil hydraulic fluids may behave likewise. 

Surfactants may increase the solubility of the drug via micelle formation, but the amounts of material required to increase solubility significantly are such that at least orally the laxative effects are likely to be unacceptable. The competition between the surfactant micelles and the absorption sites is also likely to reduce any useftd effect and make any prediction of net overall effect difficult. However, if a surfactant has any effect at all, it is likely to be in the realm of agents that help disperse suspensions of insoluble materials and make them available for solution. Natural surfactants, in particular bile salts, may enhance absorption of poorly soluble materials. 

Where a foodstuff contains a sweetener or sweeteners, as allowed, the statement with sweetener/s must accompany the name of the product. Where a foodstuff contains both added sugar and sweeteners, as allowed, the statement with sugar/s and sweetener/s must accompany the name of the product. Foodstuffs that contain aspartame must bear the statement contains a source of phenylalanine . Foodstuffs that contain more than 10% added polyols must bear the statement excessive consumption may produce laxative effects . 

Metabolism via normal metabolic pathways or fast excretion without metabolism are desirable characteristics. Some intense sweeteners are excreted unchanged while others are metabolised. Bulk sweetener absorption is lower and slower than for carbohydrates and results in reduced caloric availability which is partly due to metabolites formed by intestinal bacteria. Such metabolites and osmotic effects of not fully absorbed bulk sweeteners can cause laxative effects. Generally, the calorific value of bulk sweeteners is lower than for carbohydrates. Intense and bulk sweeteners are, as far as they are metabolised, not dependent on insulin. They are therefore acceptable for diabetics as part of a suitable diet. 

For bulk sweeteners, which are often an important and sometimes the most important ingredient, any limitation would be unreasonable and often even render their use impossible. In the EU consumers are alerted of potential laxative effects by labelling of products containing more than 10% by weight of sugar alcohols. 

Because of the diaphoretic and laxative effects, the composition of Sambuci flos (Sambucus negra L., black elder) has been extensively investigated by TLC. Samples for TLC analysis were preparated by refluxing 1.0 g of air-dried, powdered flowers of Sambucus negra with 10 ml of methanol for 30 min. The suspension was filtered, and the filtrate was concentrated and redissolved in 5 ml of methanol. Separation was performed on silica layers using 10 different mobile phases 1 = ethyl acetate-formic acid-acetic acid-water (100 11 11 27, v/v) 2 = ethyl acetate-formic acid-water (8 1 1, v/v) 3 = ethyl acetate-formic acid-water (88 6 6, v/v) 4 = ethyl acetate-methyl-ethyl ketone-formic acid-water (50 30 10 10, v/v) 5 = ethyl acetate-methyl-ethyl ketone-formic acid-water (60 15 3 2, v/v) 6 = ethyl acetate-formic acid-acetic acid-methyl-ethyl... 

Elemental sulfur is a yellow solid, in which eight snlfnr atoms form a crown-shaped ring Ss. Unlike elemental white phosphorus, elemental snlfnr has very low toxicity. Years ago, people in the United States took a preparation of snlfnr and molasses as a spring tonic. Taken orally, sulfur has a mild laxative effect. Beyond that, it is not clear to me what favorable effects this tonic may have had, if any. There is a lot of snlfnr aronnd. When taken in all its forms, it accounts for nearly 2% of the weight of the crnst of the Earth. 

Autonomic ganglia. Ganglionic stimulation occurs in both the sympathetic and parasympathetic divisions of the autonomic nervous system. Parasympathetic activation results in increased production of gastric juice (smoking ban in peptic ulcer) and enhanced bowel motility ( laxative effect of the first morning cigarette defecation diarrhea in the novice). 

Since food has a buffering effect, antacids are taken between meals (e.g., 1 and 3 h after meals and at bedtime). Nonabsorbable antacids are preferred. Because Mg(OH)2 produces a laxative effect (cause osmotic action, p. 170, release of cholecystokinin by Mg, or both) and Al(OH)3 produces constipation (cause astringent action of AP, p. 178), these two antacids are frequently used in combination. 

Osmotic laxative effects are also produced by the polyhydric alcohols, mannitol and sorbitol, which unlike glucose cannot be transported through the intestinal mucosa, as well as by the non-hydrolyzable disaccharide, lactubse. Fermentation of lactulose by colon bacteria results in acidification of bowel contents and microfloral damage. Lactulose is used in hepatic failure in order to prevent bacterial production of ammonia and its subsequent absorption (absorbable NH3 nonabsorbable NH4+), so as to forestall hepatic coma. 

Magnesium-containing antacids - Laxative effect as saline cathartic, may cause diarrhea hypermagnesemia in renal failure patients. 

Adults - 30 to 45 mL 3 or 4 times daily. Adjust dosage every day or two to produce 2 or 3 soft stools daily. Hourly doses of 30 to 45 mL may be used to induce rapid laxation in the initial phase of therapy. When the laxative effect has been achieved, reduce dosage to recommended daily dose. Improvement may occur within 24 hours, but may not begin before 48 hours or later. Continuous long-term therapy is indicated to lessen severity and prevent recurrence of portal-systemic encephalopathy. 

These laxatives act by softening and increasing faecal mass thus promoting normal peristalsis. The outer layers of cereal grains, especially wheat, form an important source of natural fibre in the diet and by increasing faecal mass natural fibre has laxative effects. 

Hypotriglyceridemic activity. Fixed oil of the bran, administered orally to adults of both sexes at a dose of 30 mg/day, was active. Flour bran, administered orally to adults at a dose of 3 g/day, was inactive . Laxative effect. Powdered dried bran, administered orally to 44 adults at a dose of 30 g/person, was active on gastrointestinal motility. Transit time decreased by 8 hours, and fecal mass increased by 48.6 g/day ". 

Laxative effect. Seed hull, taken orally by adults at a dose of 7 g/person, increased weekly fecal mass without influencing transit time or frequency . Seedcoat, administered orally to 80 patients at a dose of 6.4 g/person three times daily, was active in a blinded placebo controlled study of efficacy of extract in treatment of irritable bowel syndrome " . Water extract of the dried kernel, administered orally to 40-year-old adults of both sexes, was active . Seed powder, administered orally to adults of both sexes, was active. Biological activity reported has been patented ". Dried seeds, administered orally to adults at a dose of 0.5 g/person, were active. Placing the seeds in water increased their volume, 90% alcohol produced a decrease in volume to normal seed size, and linseed oil had no effect on volume. The seed mucilage remained in gel form and is considered preferable to the solid form because it is more easily digested " . Dried seed powder, administered orally to 35 patients with chronic constipation at a dose of 50 mg/person, was active in a controlled, double-blind study " . Fiber, administered orally to adults, was active. Psyllium fiber and sennosides were prepared into a wafer to be... 

Iran. Oil of dried seeds is taken orally for its laxative effect . 

Mechanism of Action A GI stimulant that has a direct effect on colonic smooth musculature by stimulating the intramural nerve plexus. Therapeutic Effect Promotes fluid and ion accumulation in the colon, increasing peristalsis and producing a laxative effect. 

Mechanism of Action A laxative prepared from the bean of the castor plant but the exact mechanism of acfion is unknown. Acts primarily in the small intestine. Maybe hydrolyzed to ricinoleicacid which reduces net absorption of fluid and electrolytes and stimulates peristalsis. Therapeutic Effect Increases peristalsis, promotes laxative effect. 

Danthron (1,8 dihydroxyanthraquinone) derivatives occur in senna, cascara, rhubarb. They are highly effective, and the main side effect is excessive laxative effect and abdominal pain. Danthron reparations shouid oniy be used in older patients and the terminally ill because of the risk of lepatotoxicity. 

N.A. Glucose, flavonoids, vitamins, enzymes.99 A gentle laxative effect, treats tumors, swellings and gum abscesses. 

N.A. Malva mtundifolia L. M. sylvestris L. Flavonol glycosides, gossypin-3-sulfate, mucilage, tannins, anthocyanin, malvin." A demulcent, a poultice to reduce swelling and draw out toxins. Internally to reduce gut irritation, laxative effect. 

N.A. Rosa canina L. R. damascena Mill. R. gallica L. Malic acid, citric acids, pectin, geraniol, citronellol, vitamins , complex.102 07 60 Astringent, mild diuretic and laxative effect. Excellent source of vitamin C when it s fresh. 

---