Antacids calcium-containing

Calcium-containing antacids—rebound hyperacidity, metabolic alkalosis, hypercalcemia, vomiting, confusion, headache, renal calculi, and neurologic impairment... 

Magnesium-containing products may produce a laxative effect and may cause diarrhea aluminum- or calcium-containing antacids may cause constipation magnesium-containing antacids are used to avoid bowel dysfunction. 

Thiazide diuretics, calcium-containing antacids, vitamin D, and lithium... 

Most of the interactions with mycophenolate mofetil and enteric-coated MPA are due to reductions in intestinal absorption. Aluminum-, magnesium-, or calcium-containing antacids decrease the peak level and overall exposure of MPA from either of the preparations.11 If a patient requires liquid antacids, they should be administered at least 4 hours before... 

Aluminum hydroxide and calcium-containing antacids may reduce LDL cholesterol and increase the HDL/LDL ratio. 

NaHCOs and CaCOs can neutralize HCl rapidly, depending on particle size and crystal structure, and effectively. NaHCOs acts rapidly but absorption of unneutralized NaHCOs produces risks for alkalosis and sodium retention which may lead to edema, hypertension or heart failure. Also neutralized antacids may cause alkalosis by permitting the absorption of endogenous NaHCOs. Ca + may stimulate the secretion of gastrin and HCl and calcium-containing antacids have been associated with rebound acid hypersecretion. 

Iron [P] Decreased gastrointestinal absorption of iron with calcium-containing antacids. 

Antacids. See the relevant sections for the interactions of antacids. Antacids such as aluminium-, magnesium- and calcium-containing antacids and sodium bicarbonate reduce the absorption of iron and also of drugs that require an acidic pH in the stomach for their optimal uptake. 

In a pregnant woman, calcium-containing antacids raised the calcium concentration to the point where hemodialysis was required (SEDA-17, 413). 

Recall that calcium is a factor in the stimulation of the release of gastric acid. Thus, a calcium-containing antacid will first neutralize stomach acid, bringing the pH up, but the calcium may then produce a "rebound effect by stimulating release of additional acid. 

Aluminum-containing antacids are used cautiously in patients with gastric outlet obstruction. M iesium- and aluminum-containing antacids are used cautiously in l atients with decreased kidney function. The calcium-containing antacids are used cautiously in patients witli resiiiratoiy insufficiency, renal impairment, or cardiac disease Antacids are classified as Rr iancy Category C dru and should be used witli caution during pr nancy. 

A. Oral fluoride ingestion. Administer calcium-containing antacid (calcium carbonate) orally to complex fluoride ions. 

There seem to be no direct clinical studies with calcium-containing antacids, but a clinically important interaction seems almost a certainty, based on in vitro studies with calcium carbonate, calcium in milk, (see Tetracyclines + Food or Drinks , p.347), dicalcium phosphate, and calcium as an excipient in tetracycline capsules. 

An established interaction although the information is limited. The manufacturers recommend that estramustine should be taken not less than 1 hour before or 2 hours after meals, and fhaf it should not be taken with milk, milk products, calcium-rich foods, or drugs (such as calcium-containing antacids). ... 

The manufacturer notes that aluminium/magnesium hydroxide slightly reduced the absorption of strontium ranelate (AUC decreased by 20 to 25%) when given either at the same time or 2 hours before the strontium. However, when the antacid was given 2 hours after strontium, absorption was barely affected. Therefore, the manufacturers recommend that antacids should be taken 2 hours after strontium ranelate. However, because it is also recommended that strontium ranelate is taken at bedtime, they say that, if this is impractical, concurrent intake is acceptable. Note that calcium-containing antacids would have a greater effect, see (b) below, and concurrent intake would not be recommended. 

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