Integrins functions

Arnold M, Cavalcanti-Adam EA, Glass R, Bliimmel J, Eck W, Kantlehner M, Kessler H, Spatz JP (2004) Activation of integrin function by nanopattemed adhesive interfaces. ChemPhysChem 5 383-388... 

Shimaoka M, Springer TA. Therapeutic antagonists and conformational regulation of integrin function. Nat Rev Drug Discov 2003 2 703-16. 

The integrin-mediated activation of MAPK pathways seem particularly important for integrin function since this has an influence on transcription processes. The model of the mechanism of this linkage usually employs the Ras protein as a central switching... 

Verfaillie CM, Hurley R, Zhao RC et al. Pathophysiology of CML do defects in integrin function contribute to the premature circulation and massive expansion of the BCR/ABL positive clone JLab Clin Med 1997 129 584-591. 

Salter, D.M., Robb, J.E. and Wright, M.O. (1997) Electrophysiological responses of human bone cells to mechanical stimulation evidence for specific integrin function in mechanotransduction. Journal of Bone and Mineral Research 12 1133-1141... 

Pande G (2000) The role of membrane lipids in regulation of integrin functions. Curr Opin Cell Biol 12 569-574... 

Memmo LM, McKeown-Longo P (1998) The alpha v beta 5 integrin functions as an endocytic receptor for vitronectin. J Cell Sci 111 425-433... 

In a first experiment with fibroblasts in culture, an extended 73-nm-spaced pattern was compared with a 2-pm-patterned 58-nm array. Although the total nanoparticle density of the micropatterned surface was considerably lower than that of the homogeneously coated one, the cells could only form FAs on 58-nm-spaced RGD motives. It is thus obvious that integrin function critically depends on the spatial confinement of integrins to favour clustering but not on the total number of bound integrins [82],... 

Wei Y, Eble JA, Wang Z, Kreidberg JA, Chapman HA. Urokinase receptors promote betal integrin function through interactions with integrin alpha3betal. Mol Biol Cell 2001 12(10) 2975-2986. 

At micromolar concentration range, calcium enhances the integrin functions while calcium inhibits integrin fimction in the mM concentration range. Magnesium and manganese... 

Li W, Metcalf DG, Gorelik R, Li R, Mitra N, Nanda V, Law PB, Lear ID, Degrade WE, Bennett IS. A push-pull mechanism for regulating integrin function. Proc. Natl. Acad. Sci. U.S.A. 2005 102 1424-1429. 

BakerEK,TozerEC,PfaffM, etal. A genetic analysis of integrin function Glanzmanndwolidrasihenia in vitro. ProcNatl Acad Sd (USA) 1997 94 1972-1978. 

Levite M, Chowers Y, Ganor Y, Besser M, Hershkovits R, Cahalon L (2001) Dopamine interacts directly with its D3 and D2 receptors on normal human T cells, and activates betal integrin function. Eur J Immunol 31 3504—3512. 

Integrin function. The cytoplasm is on the left, separated from the extracellular space by the plasma membrane, shown in gray. The transmembrane protein, shown in purple, is an integrin. It is attached to the actin cytoskeleton inside the cell and to the extracellular matrix through an interaction with an RGD motif on fibronectin. 

Leitinger B, McDowall A, Stanley P and Hogg N (2000) The regulation of integrin function by Ca( 2+). Biochim Biophys Acta 1498 91-98. 

Jones P H, Watt F M (1993). Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell. 73 713-724. 

Miyamoto, S., Teramoto, H., Coso, OA. et al. (1995). Integrin function molecular hierarchies of cytoskeletal and signaling molecules, y. Cell Biol. 131, 791-805. 

Keller, R.S., S.Y. Shai, C.J. Babbitt, C.G. Pham, R.J. Solaro, M.L. Valencik, J.C. Loftus, and R.S. Ross. 2001. Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance. American Journal of Pathology 158(3) 1079-90. 

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